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Advancing Scalable Alcohol Brief Interventions in the ED: A Trial of Conversational AI With Digital Reinforcements

ConditionAlcohol Misuse
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorStanford University

About this trial

The goal of this clinical trial is to learn if a novel digital strategy combining a generative AI counseling agent (MICA) and weekly SMS boosters works to reduce risky drinking among Emergency Department patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

For men: AUDIT-C score 4+

For women: AUDIT-C score 3+

Owns a mobile phone

Reads English language

Disqualifiers

For women: current or planned pregnancy in next 12 months

Prisoner

Trial design

Design model

Parallel

Treatments tested in this trial

  • MICA

    Behavioral

    MICA is an AI chatbot that uses a secure API with ChatGPT and prompted to follow MI principles to support individuals in exploring and resolving ambivalence about their alcohol use. MICA follows a predefined conversational framework and steps: introduction, engagement, focusing, evoking, planning, and closing-adapted from Miller \& Rollnick's Motivational Interviewing: Helping People Change (3rd ed.).

  • TRAC

    Behavioral

    Weekly SMS check-ins designed to support goal-setting, self-monitoring, and adaptive self-regulation strategies. Beginning the Sunday after enrollment, participants will engage with an automated SMS program once weekly for 12 weeks. Prompts include reporting on the past week's alcohol use and whether they are willing to commit to a drinking limit goal for the upcoming week. Responses trigger tailored feedback.

Treatment groups

750 Participants
are divided into 3 treatment groups
Group A: MICAExperimental treatment 1 intervention
Group B: MICA+SMSExperimental treatment 2 interventions
Group C: Standard careNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Mean weekly alcohol consumption

Participants report (1) the average number of standard alcohol drinks each day of the week. Estimated weekly alcohol consumption will be calculated as the sum of all those drinks over 7 days.

Time frame
Baseline, 3-, 6-, and 12-month follow-ups

Secondary outcomes

1

Number of heavy drinking days

Asking participants: "Over the past 30 days, how many days did you have 4+ standard drinks (women) / 5+ standard drinks (men)?"

Time frame
Baseline, 3-, 6-, and 12-month follow-ups
2

Max number of drinks per drinking day

Asking participants, "Over the past 30 days, what is the most drinks you had on any single day?"

Time frame
Baseline, 3-, 6-, and 12-month follow-ups
3

AUDIT score

Alcohol Use Disorders Identification Test (AUDIT) is a 10 question screen for AUD

Time frame
Baseline, 3-, 6, 12-months

Other outcomes

1

SIP-2R

Short Inventory of Problems (SIP-2R) is a 15-item questionnaire used to measure the negative consequences and harm caused by drinking alcohol

Time frame
Baseline, 3-, 6-, and 12-months

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Stanford University

Lead sponsor

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: