Health TrialsbyHealthPanel

Aerobic vs Resistance Exercise in Post-menopausal Women With Type 1 Diabetes

ConditionsType 1 DiabetesPost-menopause
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age45-75
SponsorUniversity of Alberta

About this trial

Participants will be asked to wear a continuous glucose monitor for at least three days on three separate occasions. One testing session will be a no-exercise resting control session (90 minutes). One will be a moderate aerobic exercise session (30 minutes of exercise, 60 minutes of recovery), and the third will be a moderate weight-lifting session (\~30 minutes of exercise, 60 minutes of recovery).The investigators will measure changes in blood glucose during exercise by drawing blood during and after exercise. Post-exercise glucose trends will be examined using continuous glucose monitoring.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

type 1 diabetes, diagnosed for at least one year

post-menopause (at least one year since last menstrual period), or have had a hysterectomy and bilateral salpingo oophorectomy

able to perform aerobic and resistance exercise

able to visit the lab in Edmonton, Alberta (University of Alberta)

Disqualifiers

HbA1c > 9.9 %

frequent and unpredictable hypoglycemia

change in insulin management strategy within the last 2 months

blood pressure > 140 / 95

Trial design

Design model

Single group

Treatments tested in this trial

  • Aerobic Exercise

    Other intervention

    Walking at 60% of maximal aerobic capacity on a treadmill

  • Resistance Exercise

    Other intervention

    Performing one set of 10 repetitions of 10 different weight-lifting exercises

  • No exercise

    Other intervention

    Participants will rest in a supine position for 30 minutes.

Treatment groups

20 Participants
are divided into 1 treatment group
Group A: All participantsExperimental treatment 3 interventions

Trial outcomes

Primary outcomes

1

Blood glucose

Change in blood glucose

Time frame
From 0 minutes to 45 minutes (beginning to the end of exercise/control) and then for 60 minutes after exercise

Secondary outcomes

1

mean continuous glucose monitoring (CGM) glucose

mean of all measurements over the selected time frames

Time frame
6 hours, 12 hours, nocturnal (midnight to 6am) and 24 hours post-exercise
2

coefficient of variation (CV) of CGM glucose

CV of CGM glucose over the selected time frames

Time frame
6 hours, 12 hours, nocturnal (midnight to 6am) and 24 hours post-exercise
3

standard deviation (SD)

SD of CGM glucose over the selected time frames

Time frame
6 hours, 12 hours, nocturnal (midnight to 6am) and 24 hours post-exercise
4

frequency of hypoglycemia

number of times that CGM glucose is equal to or less than 3.9 mmol/L

Time frame
6 hours, 12 hours, nocturnal (midnight to 6am) and 24 hours post-exercise

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Alberta

Lead sponsor

Women and Children's Health Research Institute, Canada

Collaborator

Source ClinicalTrials.gov
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