About this trial
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality. Imaging of the meiotic spindle may be crucial for determining the oocyte maturation. Artificial intelligence (AI) will be applied to establish the complex oocyte quality, embryo ploidy and pregnancy success probability from the sequence of data, starting with the recording of the meiotic spindle in polarized light, through paternal factors up to the time lapse recording of early embryo development. This strategy should reduce the cost of fertility treatment thanks to increased efficiency in choosing the most promising candidates and reducing the need for costly laboratory analyses.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Intracytoplasmatic Sperm Injection
Preimplantation genetic testing
Time lapse embryo record
Singned informed consent
Disqualifiers
Gynecological diseases
Genetical diseases of parents
Trial population
Infertility couples, where ICSI and PDT are indicated
Trial design
Cohort
Prospective
Treatments tested in this trial
arteficial inteligence evaluation of oocyte and embryo development
Procedure/Surgeryapply AI to find out the complex oocyte quality, embryo development, embryo ploidy and pregnancy success probability from the sequence of the data starting from the recording of the meiotic spindle in polarized light, through paternal factors up to the time lapse record of early embryo development.
Treatment groups
Trial outcomes
Primary outcomes
The relative number of embryos whose ploidy was correctly predicted by AI
Using an AI based non-invasive method of selecting a high-quality and genetically healthy embryos will undoubtably improve clinical and diagnostic practice and reduce costs in the field of infertility treatment. Both the segmentation and classification training will be based on expert annotations. The approach should lead to a classification accuracy at least 70%.
Sponsors and contacts
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Charles University, Czech Republic
Lead sponsor
Czech Academy of Sciences
Collaborator
Czech Technical University in Prague
Collaborator
General University Hospital, Prague
Collaborator