Aging and Exercise Impacts on Glymphatic Function
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-75
SponsorUniversity of Texas Southwestern Medical Center
About this trial
This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range. This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function. There will be no randomization, and all enrolled subjects will participate in the exercise session.
Hypotheses: revealed by the multi-modal magnetic resonance imaging (MRI) approach, glymphatic dysfunction increases with age and is associated with preclinical Alzheimer's Disease (AD) pathology in cognitively unimpaired individuals. Using acute aerobic exercise as a human model, the enhancement of cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange caused by elevated cardiac activity and paravascular cerebrospinal fluid (pCSF) dynamics can be validated.
Eligibility criteria
Qualifiers
age 25-75 years old
cognitively unimpaired (CU)
Mini-Mental State Examination (MMSE) score ≥27 at enrollment screening
matched gender
Disqualifiers
pregnant women
history of stroke or other major cerebrovascular disease;
diagnosis of Alzheimer's disease (AD) or other types of dementia;
diagnosis of major neurologic and psychiatric disorders (e.g., Parkingson's disease, major depression);
Trial design
Treatments tested in this trial
- Acute Aerobic exercise
Treatment groups
240 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
University of Texas Southwestern Medical Center
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov