AI-based Predictive and Interventional System for Early Detection of Non-compliance Risks With Oral Therapies in Lymphoma Patients.

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorGrand Hôpital de Charleroi

About this trial

This research forms part of a continuous quality improvement initiative. It aims to assess patient compliance of oral therapies by artificial intelligence. It could overcome the limitations of current practices and enhance the responsiveness and accuracy of clinical interventions.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

All patients aged 18 and over who are treated in the Haematology Department at the Grand Hôpital de Charleroi from November 2025 onwards

Treated for a lymphoma, Non Hodgkin

Capable of giving informed consent

Disqualifiers

All other patients who did not meet the eligibility criteria

Trial population

Patients treated in the Haematology Department at Charleroi General Hospital for Non-Hodgkin lymphoma.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Retrospective Group

    Other intervention

    For the retrospective group of 20 patients.

  • Prospective Group

    Other intervention

    Follow-up of the patients for the prospective group

Treatment groups

210 Participants
are divided into 2 treatment groups
Group A: Retrospective cohort1 intervention
Group B: Prospective cohort1 intervention

Trial outcomes

Primary outcomes

1

ROC-AUC

Description: ROC-AUC : Receiver Operating Characteristic - Area Under the Curve is a performance metric for binary classification prediction algorithms. ROC Curve: Plots the True Positive Rate (sensitivity) against the False Positive Rate (1-specificity) at various classification thresholds. AUC: The area under this curve (ranging from 0 to 1). A higher AUC indicates better model performance-1.0 is perfect, 0.5 is random guessing. ROC-AUC evaluates how well the model distinguishes between classes, regardless of the classification threshold. Time Frame: When the data will be avalaible, at the end of 2027

Time frame
2027

Secondary outcomes

1

F1-score

F1-Score is a performance metric for classification algorithms, the harmonic mean of Precision (correct positive predictions / total positive predictions) and Recall (correct positive predictions / actual positives). Formula: F1 = 2 × (Precision × Recall) / (Precision + Recall) Range: 0 to 1, where 1 is perfect precision and recall, and 0 is the worst. F1-Score balances precision and recall, making it ideal when you need to avoid both false positives and false negatives.

Time frame
When the data will be avalaible, at the end of 2027

Other outcomes

1

Recall for the positive class

Recall for the positive Class is a metric for binary classification that answers: "What proportion of actual positives was correctly identified by the model?" Formula: Recall = True Positives / (True Positives + False Negatives) Range: 0 to 1, where 1 means all positives were correctly predicted, and 0 means none were. High recall means the model is good at capturing most positive cases, but it may also include more false positives. It's critical when missing a positive (false negative) is costly.

Time frame
2027

Sponsors and contacts

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