Aim 3 Particle Swarm Optimization PIGD
ConditionParkinson's Disease and Parkinsonism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorUniversity of Minnesota
About this trial
In Parkinson's disease (PD) patients undergoing standard-of-care Deep Brain Stimulation (DBS) therapy, to compare the effect on Parkinson's symptoms of two different neurostimulator settings designed to differ from each other as much as possible with respect to how much they activate two different neuroanatomical structures: the axonal pathway from Globus Pallidus (GP) to Pedunculopontine Nucleus (PPN), and the axonal pathway from PPN to GP.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosis of Parkinson's Disease
Bilateral DBS in STN or GP
At least 3 months after lead implantation
Between 18-85 years of age
Disqualifiers
Inability to walk in the off-med, off-stimulation condition (even with safety harness)
Gait impaired significantly by a condition other than PD
Breaks or shorts in active contacts
IPG battery nearing end of life (in patients with primary-cell IPGs)
Trial design
Design model
Single group
Treatments tested in this trial
DBS
DeviceDeep Brain Stimulation
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Unified Parkinson's Disease Rating Scale Movement Disorders Society revision, MDS-UPDRS
Difference in scores on MDS-UPDRS
Time frame
1 hour and 2 weeks after intiating stimulationSponsors and contacts
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Source ClinicalTrials.gov