Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-30
SponsorUniversity of Illinois at Urbana-Champaign

About this trial

The study investigates the effects of alcohol consumption on social and individual behaviors using a within-subject design. Participants, aged 21-30, will attend two laboratory sessions approximately one week apart, participating as part of a dyad (pair). During one session, they will consume an alcoholic beverage, while in the other, they will receive a control beverage, with the order of conditions randomized. This design facilitates direct within-participant comparisons of behaviors and neural activity in intoxicated versus sober states.

To achieve these aims, the study employs EEG technology to explore intra-brain and inter-brain dynamics during social interactions. Additionally, validated self-report questionnaires will capture data on mood, social bonding, and other psychological variables. The findings are expected to enhance understanding of alcohol's role in social reward processes and contribute to developing evidence-based prevention and intervention strategies for alcohol use disorder.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Between the ages of 21 and 30

Regularly consumes alcohol

Disqualifiers

History of adverse reaction to the amount of beverage employed in the study

Have a history of major problems associated with alcohol

Take medications that could adversely interact with alcohol

Have medical conditions that contraindicate alcohol administration

Trial design

Design model

Single group

Treatments tested in this trial

  • Alcohol beverage

    Drug

    This intervention involves the administration of an alcohol beverage (vodka mixed with juice or soda) in a controlled laboratory setting, targeting a blood alcohol concentration (BAC) of 0.08%. The alcohol is consumed over a 36-minute period in three equal parts.

  • Control - non alcoholic beverage

    Other intervention

    This intervention involves the administration of a non-alcoholic control beverage in a controlled laboratory setting. The beverage is matched in volume and palatability to the alcohol condition but co

Treatment groups

200 Participants
are divided into 2 treatment groups
Group A: Alcohol beverage administrationExperimental treatment 1 intervention
Group B: Control condition - non alcoholic beverageOther 1 intervention

Trial outcomes

Primary outcomes

1

Inter-brain entrainment

Synchronization metrics (e.g., inter-subject PLV, inter-subject correlation) between paired participants, assessed separately in sober and intoxicated conditions

Time frame
During active laboratory beverage manipulation exposure (during or immediately after beverage administration, at which time participants in the alcohol condition will register a positive BAC)
2

Intra-brain entrainment

The comparison of EEG signal synchronization within the same participant across the alcohol and non-alcohol conditions, reflecting intra-brain activity changes due to alcohol consumption during the hyperscanning task.

Time frame
During active laboratory beverage manipulation exposure (during or immediately after beverage administration, at which time participants in the alcohol condition will register a positive BAC)
3

Event-Related Potentials (ERP)

Feedback-Related Negativity (FRN), measured both for the operating ("player") and observing ("observer") participant, with comparisons across sobriety conditions

Time frame
During active laboratory beverage manipulation exposure (during or immediately after beverage administration, at which time participants in the alcohol condition will register a positive BAC)
4

Ambulatory Drinking

Drinking behavior assessed outside the laboratory using ambulatory assessment

Time frame
14 days

Secondary outcomes

Other outcomes

Sponsors and contacts

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