Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

ConditionsSepsis Severe Sepsis Septic Shock Multi-organ Failure

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorThe University of Texas Health Science Center, Houston

About this trial

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure.

The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults with severe sepsis or septic shock on mechanical ventilation

Enrolled in the initial six hours of ICU admission

Disqualifiers

Patients with withdrawal or hospice order.

Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.

Patients with COPD.

Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Trial population

Adult patients admitted to medical intensive care unit with severe sepsis or septic shock requiring mechanical ventilation.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

30 Participants

are grouped into 1 trial group

Group A: Multi-organ failure

Trial outcomes

Primary outcomes

Multi-organ failure

Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.

Time frame

daily for 48 hours then weekly for 2 weeks.

Secondary outcomes

Mortality

All the patient will be followed up to 28-days to determine survival.

Time frame

ICU mortality

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

The University of Texas Health Science Center, Houston

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: