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AM vs PM Exercise Training

ConditionHypertension
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age55-80
SponsorMichigan State University

About this trial

The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with the body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise training performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Systolic BP equal to or greater than 130 mmHg without BP medication or greater than 120 mmHg with medication and diastolic blood pressure equal to and greater than 80 mmHg

55-80 years old

Post-menopausal female

Able to walk without assistance

Disqualifiers

Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week

Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension

Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months

Cancer within last 5 years

Trial design

Design model

Crossover

Treatments tested in this trial

  • 6 weeks of exercise training (Pre-training)

    Behavioral

    handgrip and treadmill walking 4 days per week

  • 6 weeks of exercise training (Post-training)

    Behavioral

    handgrip and treadmill walking 4 days per week

Treatment groups

79 Participants
are divided into 2 treatment groups
Group A: Morning (AM)Experimental treatment 2 interventions
Group B: Evening (PM)Experimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Nocturnal systolic blood pressure (BP)

Change in systolic nocturnal BP (Pre-training - Post-training)

Time frame
6 weeks

Secondary outcomes

1

Endothelial function

Change in flow mediated dilation of the brachial artery (Post-training - Pre-training)

Time frame
6 weeks
2

Microvascular function

Change in rapid onset vasodilation of the popliteal artery

Time frame
6 weeks
3

Ambulatory blood pressure

Change in systolic and diastolic BPs over a 24-hr period (Pre-training - Post-training)

Time frame
6 weeks
4

Arterial stiffness

Change in carotid femoral pulse wave velocity (Pre-training - Post-training)

Time frame
6 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Michigan State University

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Source ClinicalTrials.gov
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