Amino Acid Supplementation in Continuous Renal Replacement Therapy
ConditionAcute Kidney Injury
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorKarolinska University Hospital
About this trial
ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment.
Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Dialysis where amino acid supplementation is planned by treating physician
Disqualifiers
Liver failure
Muscle disease
Neurodegenerative disease
Trial design
Design model
Single group
Treatments tested in this trial
Amino acid supplementation (Glavamin, Fresenius Kabi)
Dietary supplementMixture of amino acids (67 g / 500 ml) given intravenously
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: All patientsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Balance of amino acids
Total balance of amino acid losses and supplementation given
Time frame
After 3 days of dialysisSecondary outcomes
1
Amino acid concentration in plasma
Concentration of various amino acids in plasma without and with supplementation
Time frame
After 3 days of dialysis2
Concentration of vitamins and trace elements
Analysis of various trace elements and vitamins
Time frame
After 3 days of dialysisSponsors and contacts
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Source ClinicalTrials.gov