Anabolic Response To Intravenous Amino Acids In Chronic Intestinal Failure Patients
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorInstitute of Oncology Ljubljana
About this trial
The purpose of this study is to gain insight into the actual protein requirements of patients with chronic intestinal failure (CIF) receiving home parenteral nutrition, which could improve clinical management of these patients. Based on collected data on protein kinetics, the study aims to further refine and personalize nutritional mixtures in patients with CIF. Additional aims include assessment of short-chain fatty acid metabolism and evaluation of gut microbiota function in patients with CIF.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial design
Design model
Single group
Treatments tested in this trial
Intravenous Amino Acids
DrugIntravenous amino acid administration to assess anabolic response and protein kinetics in patients with chronic intestinal failure receiving home parenteral nutrition
Treatment groups
40 Participants
are divided into 1 treatment groupGroup A: Intravenous Amino Acid AdministrationExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Whole-Body Protein Kinetics (Protein Synthesis Rate) After Intravenous Amino Acid Infusion
Protein anabolic response will be assessed by whole-body protein kinetics using a stable isotope tracer methodology during intravenous amino acid administration. The outcome will be reported as the change in whole-body protein synthesis rate (µmol/kg/h) from baseline to post-infusion.
Time frame
Baseline (prior to amino acid infusion) and immediately after amino acid infusion (within 1 day)Sponsors and contacts
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Source ClinicalTrials.gov