Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor. Accumulation in thyroid tissue may be modeled using several factors, including blood chlordecone levels, environmental exposure associated with place of residence, and dietary habits.
adult patients hospitalized at the Guadeloupe University Hospital for surgical treatment of thyroid pathology
person affiliated to or beneficiaries of a social security system
person with free, informed, and written consent signed by the participant and the investigator
patients subject to a judicial safeguard measure,
patient under 18 years old
patient without signed consent
current pregnancy at the time of inclusion
Single group
Blood and thyroid tissue collection
Other interventionCollection of blood, thyroid tissue, and adjacent adipose tissue samples during routine thyroid surgery for measurement of chlordecone concentration and assessment of exposure-related factors.
chlordecone concentration in the adipose tissue adjacent to the thyroid
Chlordecone concentration measured in adipose tissue adjacent to the thyroid collected during thyroid surgery.
Chlordecone concentration in blood
Chlordecone concentration measured in blood samples collected one day before surgery.
Occupational exposure category
Occupational activity classified as high or low potential exposure to chlordecone based on professional activity collected through a self-administered questionnaire. Agricultural workers and livestock breeders will be classified as high exposure occupations
Residential environmental exposure assessment
Environmental exposure assessment based on residential history during the previous 10 years. Residential addresses reported for periods longer than 3 months will be geolocated and linked to soil contamination maps established by CIRAD.
Dietary exposure assessment
Dietary habits assessed using a self-administered questionnaire collecting information on food consumption patterns and food origin.
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Centre Hospitalier Universitaire de la Guadeloupe
Lead sponsor
Institut Pasteur de Guadeloupe
Collaborator
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