By using 16S rRNA sequencing technology to analyze the changes in ocular surface microbiota before and after surgery, as well as the impact of changes in ocular surface microbiota on FS-LASIK induced DES, new treatment ideas are provided for corneal FS-LASIK induced DES patients, and the incidence of FS-LASIK related DES is reduced.
Age ≥ 18 years old;
Stable refractive index (refractive index change less than 0.5D in the past 2 years);
The best corrected far vision (CDVA) is 1.0 or better;
Postoperative dry eye patients need to meet the following criteria: Patient's Eye Surface Disease Index (OSDI) ≥ 13 and two of the following three criteria are met: Tear film rupture time (BUT) ≤ 10S Schirmer I test (mm/5min) ≤ 10mm, corneal fluorescein sodium staining exceeding 5 spots;
History of eye trauma or surgery;
Suspected keratoconus;
Previously suffering from other eye diseases such as keratitis or edema, glaucoma, uveitis, retinal detachment, macular degeneration, cataracts, amblyopia, etc.;
Preoperative history of severe dry eye disease;
Dry eye patients after FS-LASIK
Other
Prospective
Not listed
Sampling of conjunctival sac microbiota
Microbial diversity of conjunctival sac
Dry eye examination
Tear Film Break Up Time
Corneal nerve condition
corneal nerve fiber density
Dry eye examination
Schirmer Ⅰ test
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