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Analysis of Outcomes and Adverse Events of Patients Undergoing Radiation Therapy

ConditionsRadiotherapy; Adverse EffectRadiotherapy; ComplicationsQuality of Life
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age16-105
SponsorDaniel Zwahlen

About this trial

Analysis of outcomes and adverse events of patients undergoing radiation therapy. Quality control using data base of patient records 2000-2025

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients who are being treated with radiotherapy at the Department of Radiation Oncology at the Winterthur Cantonal Hospital

Disqualifiers

No radiotherapy at the Department of Radiation Oncology at the Winterthur Cantonal Hospital <16 years,> 105 years

Trial population

Patients who are being treated with radiotherapy at the Department of Radiation Oncology at the Winterthur Cantonal Hospital

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Radiotherapy

    Radiation

    Outcomes and adverse events using radiation therapy

Treatment groups

25,000 Participants
are divided into 1 treatment group
Group A: Data Base of Patient Records 2000-20251 intervention

Trial outcomes

Primary outcomes

1

Overall survival (OS) and progression free survival (PFS) analysis after radiation therapy

Calculation of Overall survival (OS) and progression free survival (PFS). Time-to-event endpoints are summarized as the median and corresponding 95% confidence interval using Kaplan-Meier method

Time frame
25 years
2

Analysis of risk factors influencing outcome after radiation therapy

Calculation of log-rank tests. If possible, hazard ratios are calculated via Cox regression. Competing risk analysis is conducted as supportive analysis

Time frame
25 years

Secondary outcomes

1

Number of patients with acute and late adverse events after radiation therapy

Predefined toxicity events are described by type, grade, frequency, and percentage across all time points. Fisher's exact tests are used for comparison (base line and defined time points). Quality of life symptom and function scales are used. Two-tailed tests with a significance level of 0.05 are used for all analyses. Adjustments for multiple testing may be used. Some of the analyses are exploratory and hypothesis generating

Time frame
25 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Daniel Zwahlen

Lead sponsor

Kantonsspital Winterthur KSW

Sponsor institution

Source ClinicalTrials.gov
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