About this trial
The study is a retrospective observational study. The study is designed to be multicentric and international and it will analyze medical records from selected patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy.
There are no risks for the patients, as this is a retrospective data collection.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosis of clinical or pathological stage IIB (T1-2, hilar N1, M0) and III (any T, N1-2, M0) NSCLC surgically treated with robotic, VATS and open approach with radical intent from 1st of January 2016 to 31st of March 2024
Received neoadjuvant chemo-immunotherapy or immunotherapy alone
Age >= 18 years old at the moment of surgery
Disqualifiers
Age <18 years old at the moment of surgery
Trial population
Patients with diagnosed locally advanced and resectable non-small cell lung cancer (NSCLC) who underwent lung resection from 01-01-2016 to 31-03-2024 by robotic, video-assisted thoracoscopic (VATS), and open approaches after receiving neoadjuvant chemo-immunotherapy.
Trial design
Cohort
Retrospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
The perioperative complication of video-assisted thoracoscopic surgery (VATS) approach
The investigators will measure the perioperative complications of VATS approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
The perioperative complications of robotic approach
The investigators will measure the perioperative complications of robotic lung resection in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
The perioperative complications of the open approach
The investigators will measure the perioperative complications of open approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
Secondary outcomes
Duration of surgery
Duration of the surgery based on the approach measured in minutes
Quality of lymphadenectomy
Number of lymphonodes station resected
Conversion rate
Number of surgery procedures converted
Radicality of the resection
Radicality of the resection in the approaches
Sponsors and contacts
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Scientific Institute San Raffaele
Lead sponsor
Memorial Sloan Kettering Cancer Center
Collaborator
Istituto Clinico Humanitas
Collaborator
Regina Elena Cancer Institute
Collaborator
Baptist Health South Florida
Collaborator
West Virginia University
Collaborator