The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for caries risk.
The main question to answer is:
• Can the host´s salivary protein profile (expression and abundance) show a correlation with the caries prevalence between the individuals in the different study cohorts?
Two cohorts of children with different documented demographic characteristics in the region of Stockholm (Sweden) will be examined.
Participants will be asked to provide saliva samples and undergo clinical oral examinations conducted by trained dental practitioners.
3-year-old children residing in the areas served by Folktandvården Danderyd and Järva, respectively
Written consent, signed by both parents (guardians)
children older than three years
medication intake, and antibiotic use at the time of examination
children who have consumed food, drink, or used oral hygiene products within 2 hours before the dental visit
children who appear uncooperative during saliva sampling
Children will be recruited in conjunction with their mandatory three-year examination at two of Folktandvården's clinics: Järva (care need area 3-4) and Danderyd (care need area 1-2). Dental care is free for children, and the first oral health status examination by a dentist is routinely performed when the child turns three years old. Therefore, Folktandvården's clinics in Stockholm organize events (3-year-old parties) where the first examination of 3-year-old children is conducted. This is a unique opportunity to simultaneously call in and examine community groups of children of the same age, with comparable environmental and socioeconomic factors. We are therefore aiming for two study cohorts consisting of self-defined populations with calibrated age.
Cohort
Cross-sectional
Not listed
Differential protein expression across caries severity levels
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Karolinska Institutet
Lead sponsor
Folktandvården Stockholms län AB
Collaborator
