Recent research suggests a significant link between gut microbiota and anastomotic leakage (AL) in colorectal surgery. Patients who develop AL have a higher abundance of bacteria from the Lachnospiraceae family and lower microbial diversity.
Considering the bibliographic data, our main interest is to analyze the microbial population of patients in our social environment and then look for differences in the microbiome between those who have suffered an anastomotic dehiscence (around 8-9% according to the results of our hospital's Surgery Department) and those who have not.
Patients who have undergone colorectal intestinal anastomosis.
Signing of the informed consent form.
Age ≥18 years with good functional status.
Availability for postoperative follow-up.
Emergency surgery.
Intra-abdominal sepsis or previous dehiscence.
Severe immunosuppression.
Use of antibiotics in the 3 months prior to preoperative preparation.
Patients will be selected by the clinical members of the research team from within the population in our setting who will undergo abdominal surgery involving colorectal intestinal anastomosis. To identify patients, the Surgery Department will analyze those who meet the inclusion and exclusion criteria designed for this project during the daily morning clinical session, and patients will then be offered the opportunity to accept/decline participation.
Cohort
Prospective
Not applicable- observational study
Other interventionFecal sample collection
Understand the patient's microbiome
To understand the microbiome of patients undergoing colorectal surgery and the effect of current surgical preparation on the microbiota in our local population.
Predictive indicators of colorectal anastomosis postsurgery
Predictive indicators of postoperative outcomes in patients undergoing colorectal anastomosis surgery through metagenomic characterization of the gut microbiota.
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