Animal and Microbial-based Dietary Protein Efficiency in Adults
ConditionProtein Metabolism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorDaniel Moore
About this trial
Given the relatively high carbon footprint and sustainability of animal-based proteins, there is a growing interest in determining the nutritional quality non-animal-based protein sources. The overall objective of this investigation is to examine the impact of different animal and microbial-based protein sources to support whole body protein synthesis in adults. To do this, investigators will employ a 'breath test' method developed in our laboratory as well as urine sampling. The results of this study will allow us to better understand the impact of dietary protein quality for maintaining health and body protein mass in adults.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy, male and female, recreationally-active participants.
Healthy will be defined as screened by the PAR-Q+ (Appendix B) and The Physical Activity Readiness Questionnaire (Appendix C).
Participants will be aged 18-45 years old.
Participants are willing to abide by the compliance rules of this study.
Disqualifiers
Inability to adhere to any of the compliance rules judged by principal investigator (e.g. dairy protein or yeast allergy).
Self-reported regular tobacco use.
Self-reported illicit drug use (e.g., growth hormone, testosterone, etc.).
Individuals who have participated in studies within the past year involving any of the stable isotopes in the study.
Trial design
Design model
Crossover
Treatments tested in this trial
Yeast Protein Supplement
Dietary supplementEach protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
Whey Protein Isolate Supplement
Dietary supplementEach protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
Collagen Hydrolysate Supplement
Dietary supplementEach protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
Treatment groups
13 Participants
are divided into 3 treatment groupsGroup A: Yeast Protein SupplementExperimental treatment 1 intervention
Group B: Whey Protein Isolate SupplementActive comparator 1 intervention
Group C: Collagen Hydrolysate SupplementActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
1. Phenylalanine excretion (umol/kg/h)
Whole body phenylalanine excretion determined from the product of breath 13CO2 enrichment and carbon dioxide production rate (VCO2).
Time frame
8 hours2
Phenylalanine oxidation (umol/kg/h)
Whole-body phenylalanine oxidation determined from the correction of phenylalanine excretion by the phenylalanine precursor enrichment determined from urine enrichment over the 8 hour measurement period.
Time frame
8 hoursSponsors and contacts
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Source ClinicalTrials.gov