Antegrade Autologous Blood Reinfusion After CPB
ConditionCoronary Artery Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorKocaeli City Hospital
About this trial
This prospective observational study aims to evaluate the effect of antegrade pump blood reinfusion using the crystalloid "chase" technique on postoperative transfusion requirements in adult patients undergoing cardiac surgery with cardiopulmonary bypass. At the end of cardiopulmonary bypass, blood remaining within the cardiopulmonary bypass circuit is reinfused antegradely through the arterial line using a crystalloid chase, without collection or storage. Blood remaining within the bypass circuit after surgery represents a valuable source of autologous blood, and its reinfusion may contribute to perioperative blood conservation strategies. Patients receiving antegrade pump blood reinfusion via the chase technique will be compared with those managed without reinfusion, without any intervention by the investigators. The primary outcome is postoperative blood transfusion requirement.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 to 80 years
Patients undergoing elective, isolated coronary artery bypass grafting surgery using cardiopulmonary bypass (on-pump).
Disqualifiers
Emergency or Redo cardiac surgery
Concomitant cardiac procedures (e.g., valve repair/replacement or aortic surgery).
Planned or intraoperative conversion to off-pump coronary artery bypass grafting
Preoperative hematocrit <30% or known inherited/acquired bleeding disorders.
Trial population
The study population includes adult patients (18-80 years) scheduled for elective, primary isolated coronary artery bypass grafting (CABG) using cardiopulmonary bypass at Kocaeli City Hospital.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Antegrade Pump Blood Reinfusion
Procedure/SurgeryAdult patients undergoing cardiac surgery with cardiopulmonary bypass in whom antegrade pump blood reinfusion is performed at the end of bypass using the crystalloid chase technique, as part of routine clinical practice.
No Anterograde Pump Blood Reinfusion
Other interventionAdult patients undergoing cardiac surgery with cardiopulmonary bypass in whom anterograde pump blood reinfusion is not performed at the end of bypass. Standard institutional clinical management is applied.
Treatment groups
130 Participants
are divided into 2 treatment groupsGroup A: Antegrade Pump Blood Reinfusion (Chase Technique)1 intervention
Group B: No Pump Blood Reinfusion1 intervention
Trial outcomes
Primary outcomes
1
Postoperative Blood Transfusion Requirement
Incidence of allogeneic blood transfusion within the first 24 hours after surgery.
Time frame
From the end of surgery to 24 hours postoperativelySecondary outcomes
1
Postoperative Drainage Volume
Total postoperative chest drainage volume within the first 24 hours after surgery.
Time frame
From the end of surgery to 24 hours postoperatively2
Number of Transfused Blood Units
Total number of allogeneic blood transfusion units administered within the first 24 hours after surgery.
Time frame
From the end of surgery to 24 hours postoperativelySponsors and contacts
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Source ClinicalTrials.gov