This is a prospective, monocentric, randomized controlled trial to investigate the effect of anti-hypertensive treatment and/or individualized exercise training intervention on blood pressure and vascular health. Furthermore the investigators want to decipher mechanisms, which contribute to vascular health by analyzing changes in metabolism and cell function in relation to vascular reaction.
None
no written informed consent
age <18 years
isolated diastolic hypertension
medical contraindications for the exercise treatment (for example orthopedic problems or an abnormal ECG during the cardio respiratory exercise test)
Parallel
Individualized exercise therapy
BehavioralPatients in the intervention group will receive an individualized exercise training program 3x/week.
Lifestyle recommendations
BehavioralThe lifestyle recommendation group will receive general recommendations such as salt reduction, higher physical activity levels and stress reduction.
The additional effect of an anti-hypertensive treatment plus an individualizes exercise therapy on the retinal vessel diameters compared to a guideline based anti-hypertensive treatment with general lifestyle recommendations.
The retinal vessel diameters will be analyzed based on the arteriolar-to-venular diameter ratio (AVR).
Effect of an guideline based anti-hypertensive therapy on the retinal vessel diameters.
Changes of retinal vessel diameters will be analyzed based on the arteriolar-to-venular diameter ratio (AVR).
The additional effect of an anti-hypertensive treatment plus an individualizes exercise therapy on the systolic and diastolic blood pressure compared to a guideline based anti-hypertensive treatment with general lifestyle recommendations.
Changes in unattended systolic and diastolic blood pressure in mm Hg.
Effect of an guideline based anti-hypertensive therapy on the systolic and diastolic blood pressure.
Changes in unattended systolic and diastolic blood pressure in mm Hg.
The additional effect of an anti-hypertensive treatment plus an individualizes exercise therapy on the microvascular endothelial function compared to a guideline based anti-hypertensive treatment with general lifestyle recommendations.
Changes in microvascular endothelial function will be analyzed by retinal arteriolar and venular flicker light-induced dilation.
Effect of an guideline based anti-hypertensive therapy on the microvascular endothelial function.
Changes in microvascular endothelial function will be analyzed by retinal arteriolar and venular flicker light-induced dilation.
The additional effect of an anti-hypertensive treatment plus an individualizes exercise therapy on fat and muscle mass compared to a guideline based anti-hypertensive treatment with general lifestyle recommendations.
Changes in fat and muscle mass will be investigated by bioimpedance analysis.
Effect of a guideline based anti-hypertensive therapy on fat and muscle mass.
Changes in fat and muscle mass will be investigated by bioimpedance analysis.
The additional effect of an anti-hypertensive treatment plus an individualizes exercise therapy on intra- and extracellular water volume compared to a guideline based anti-hypertensive treatment with general lifestyle recommendations.
Changes in intra- and extracellular water volume will be investigated by bioimpedance analysis.
Effect of a guideline based anti-hypertensive therapy on intra- and extracellular water volume.
Changes in intra- and extracellular water volume will be investigated by bioimpedance analysis.
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