This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters.
A total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.
Being systemically healthy
Not smoking
Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months
Not being pregnant or lactating
Having a systemic disease
Smoking
Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids
Being pregnant or lactating
This study included individuals who applied to Recep Tayyip Erdogan University, Faculty of Dentistry, Department of Periodontology for treatment
Cohort
Prospective
non surgical periodontal trearment
Other interventionAll participants will receive nonsurgical periodontal treatment
anti-inflammatory nutrition education
Other interventionParticipants in Groups Q3-1 and Q4-1 will receive anti-inflammatory nutrition education
periodontal pocket depth
It will be calculated by measuring the distance between the gingival margin and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
Clinical attachment loss
It will be calculated by measuring the distance between the cementoenemal border and the pocket base. It will be measured from the six surfaces of each tooth and the average will be taken higher scores indicate worse outcome.
interleukin (IL)-1β level
IL-1β levels will be measured with biochemical kits.
interleukin (IL)-10 level
IL-10 levels will be measured with biochemical kits.
tumor necrosis factor (TNF)-α level
TNF-α levels will be measured with biochemical kits.
serum total oxidant status (TOS) level
TOS levels in serum will be measured with biochemical kits.
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Recep Tayyip Erdogan University Training and Research Hospital
Lead sponsor
Recep Tayyip Erdogan University
Collaborator
