AOSLO Imaging for the Study of Cellular Alterations in Retinal Neurodegeneration

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age10-79
SponsorCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts

About this trial

Primary objective:

\- Acquisition and analysis of images for non-medical purposes using the MONA IV system, an adaptive-optics-corrected scanning ophthalmoscope.

Secondary objectives:

* To measure the reproducibility of assessments; * To evaluate the detection of progressive changes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

100 subjects aged 10 to 79 years with a condition that may affect the inner retina (e.g., glaucoma, optic neuropathy, etc.)

100 subjects aged 10 to 80 years with a condition that may affect the outer retina (e.g., AMD, retinitis pigmentosa, etc.)

Male or female

Covered by health insurance

Disqualifiers

Inability to remain motionless on a standard ophthalmic chin rest. RETION_Protocol_v2.0 dated June 10, 2026_IDRCB: 2026-A00324-47 Page 10 of 44

Subjects taking medications or suffering from a medical condition that could interfere with the evaluations planned under the protocol;

Participants allergic to tropicamide in cases where pupil dilation is required. ☞ Wearing glasses or contact lenses to correct a refractive error is not considered an exclusion criterion.

Trial design

Design model

Single group

Treatments tested in this trial

  • MONA Imaging System

    Device

    acquisition mode with mona system

Treatment groups

260 Participants
are divided into 1 treatment group
Group A: MONA imaging systemExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Proportion of images obtained with the MONA system deemed usable for the analysis of retinal microstructures.

Images are considered usable if they allow for: * visualization of retinal microstructures (yes/no); * measurement of cell density (yes/no); * measurement of vascular diameter (yes/no).

Time frame
48 months

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

This trial is not recruiting at the moment. You can still explore other options: