Application of Different Scores in Predicting Outcomes of Cirrhotic Patients Awaiting Liver Transplantation
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorAssiut University
About this trial
the goal of this observational study is to apply different scores 1. To assess Fatigue, Frailty, Liver Transplant Comorbidity Index and MELD 3.0 in patients with liver cirrhosis awaiting liver transplantation.
2\. To evaluate the predictive accuracy of these Scores for the short-term outcomes (early complications, recurrent hospitalization and 3-month mortality). 3. To determine whether using these Scores in the pre-transplant evaluation improves risk stratification compared to MELD score alone.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
• All patients with liver cirrhosis (whatever the etiology) eligible for liver transplantation above the age of 18.
Written informed consent provided.
Disqualifiers
Old age (above 60 years old)
Acute liver cell failure without underlying cirrhosis
Absolute contraindications (e.g., uncontrolled sepsis, severe cardiopulmonary dysfunction, active malignancy).
Extra-MELD indications (e.g., hepatopulmonary syndrome, refractory ascites, cholestatic pruritus, hepatoblastoma). We restricted our cohort to patients listed for liver transplantation based on MELD-driven indications. This decision was made to reduce heterogeneity and ensure that eligibility determinations were primarily driven by MELD scores, thereby allowing us to isolate the relative contribution of frailty in the context of MELD-based allocation
Trial population
cirrhotic patients awaiting transplantation
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Waitlist morbidity and Mortality of liver transplantation
* Risk of early complications, rehospitalization and death while awaiting transplantation. 2\. Post-Transplant Survival for liver transplant recipients * 3- month survival (short-term outcome). Mortality hazard ratios associated with frailty, comorbidities, and MELD 3.0
Time frame
1.5 yearsLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: