The MRI perfusion imaging using arterial spin labeling (ASL)'s non-invasive technique (i.e. without injection of contrast medium) allows, thanks to recent technological improvement of the spatial resolution, measuring several perfusion parameter of the retinal tissue such as the regional Blood Flow (rBF) or the cerebral blood flow (cBF) expressed in ml/100g/min. Reliable application of ASL thus requires the precision and specificity of the MRI protocol to be tested.
Carrier of target pathologies: TAO optic neuropathy, inflammatory optic neuropathy, ischemic optic neuropathy.
no cardiovascular risk factors or other ophthalmological pathology
adhere to the study protocol after reading the patient information document
signe the informed consent form to participate in the study
Usual contraindications to MRI (Pacemaker, Metallic foreign body, Cochlear implant,…)
Severe claustrophobia
Parallel
MRI perfusion imaging using ASL's non-invasive technique
Diagnostic testPatients will undergo through an MRI-scan using the ASL MRI sequence, as described per protocol.
Repeatability measurement on volunteers
implementing a protocol based on 2 imaging sessions : 1st session with 2 ASL sequences and a 2nd session scheduled 5-7 days later in similar conditions including 1 ASL in volunteers will be applied. This protocol allows assessing the intra-day and the inter-day variability of the measurements using Intra-Class Correlation Coefficient and metric derived from Bland-Altman plots. A total of 20 MRI examinations are planned for this phase of the study.
Mesurement of the retinal perfusion by MRI ASL in patient in acute phase
Analysing the retinal perfusion by ASL to be able to figure out if the decreased visual acuity has an ischemic etiology.
Mesurement of the retinal perfusion by MRI ASLin patient in a chronic phase
Following up the disease process (stability, progression or reversal of the decrease in visual acuity).
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