Hemodialysis patients with xerostomia are divided into 2 groups which are group A (start with artificial saliva containing cumin and ginger extract for 2 weeks, free periods 2 weeks, then placebo for 2 weeks) and group B (start with placebo for 2 weeks, free periods 2 weeks, then artificial saliva containing cumin and ginger extract for 2 weeks). Amount of saliva (g/min), xerostomia's questionnaire, Increase of saliva score, World Health Organization Oral Mucositis Grading Scale, acid and base of saliva, quality of life's questionnaire will measure before, after using the sample for 7 and 14 days.
Age more than 18 years
Hemodialysis patients with xerostomia (saliva flow rate less than 0.2 g/min)
Hemodialysed history more than 3 months
Be willing to participate in the study
Patients with sialolith or Sjogren's syndrome
Uncontrolled other diseases
Using artificial saliva for more than 2 weeks
Taking pilocarpine and cevimeline
Crossover
Artificial saliva containing cumin and ginger extract
DrugThe sample will be sprayed 2 puff/time, 3 times/day, for 14 days.
Placebo
DrugThe sample will be sprayed 2 puff/time, 3 times/day, for 14 days.
Xerostomia symptoms using Xerostomia Inventory Score
Patients give the score of Xerostomia Inventory questionnaire. The Xerostomia Inventory Score is graded 11 to 55 (Low score means low frequency xerostomia and high score means high frequency of xerostomia)
Salivary flow rate
Weigh the saliva amount from the patients in 5 mins and then calculate in g/min
Amount of saliva score
Patients give the score of saliva amount (0 to 10, 0 means no saliva and 10 means high amount of saliva)
Quality of life score using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35
Patients give the score of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35. The score is graded 35 to 130 (Low score means high quality of life and high score means low quality of life)
World Health Organization Oral Mucositis
World Health Organization Oral Mucositis is graded 0 to 4 (0 means no mucositis to 4 means severe mucositis).
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