Asia Pediatric Intensive Care Epidemiology and Outcomes Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorKK Women's and Children's Hospital

About this trial

The overall objective of this study is to improve the standard of care of critically ill pediatric patients. The specific aims are to describe the clinical profile and outcomes of all admissions to Asian pediatric ICUs, determine the risk factors associated with poor outcomes, determine quality indicators for benchmarking ICU performance across sites and develop and train artificial intelligence algorithms to predict mortality, length of ICU stay and resource utilization.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

All patients admitted to the pediatric ICUs of participant hospitals

Disqualifiers

No consent

Trial population

Though the main methodology is recruitment of all pediatric ICU admissions, a pre-determined random sampling protocol is allowed for sites with limited in resources for recruitment and data collection. This protocol may involve recruitment of all admissions for 1year (52 weeks), all admissions for 1 month per quarter over 1 year (16 weeks), all admissions for 1 week per month over 1 year (12 weeks), all admissions for 2 weeks per quarter over 1 year (8 weeks) or all admissions for 1 week for quarter over 1 year (4 weeks) - this will be declared at the start of the study by each participating site before recruitment begins. This strategy will allow us to include sites with and without sufficient resources to be represented in this study.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

10,000 Participants
are grouped into 1 trial group
Group A: Pediatric critical illness

Trial outcomes

Primary outcomes

1

Mortality

ICU mortality and time based mortality

Time frame
Including 28-days and 60-days

Secondary outcomes

1

Ventilator duration

Ventilator duration and ventilator free days to account for mortality as competing outcome

Time frame
Including 28-days and 60-days
2

ICU duration

ICU duration and ICU free days to account for mortality as competing outcome

Time frame
Including 28-days and 60-days
3

Nosocomial infections

Including catheter related blood stream infection, catheter associated urinary tract infection hospital/ventilator associated pneumonia

Time frame
Throughout ICU stay including 28-days and 60-days
4

Accidental extubations

Unplanned extubations

Time frame
Throughout ICU stay including 28-days and 60-days

Other outcomes

1

Resource utilisation

Including ICU bed, ventilator and other ICU support utilisation. Hospital costs.

Time frame
Throughout ICU stay including 28-days and 60-days
2

Cardiopulmonary resuscitation

CPR or code blue activation within the ICU

Time frame
Throughout ICU stay including 28-days and 60-days

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

KK Women's and Children's Hospital

Lead sponsor

King Chulalongkorn Memorial Hospital

Collaborator

Tengku Ampuan Rahimah Hospital

Collaborator

King Abdullah Specialized Children's Hospital

Collaborator

Children's Hospital 2

Collaborator

University Malaysia Medical Centre

Collaborator

Saiful Anwar Hospital

Collaborator

Murni Teguh Memorial Hospital

Collaborator

Siriraj Hospital

Collaborator

Harapan Kita Women and Children Hospital

Collaborator

Vicente Sotto Memorial Medical Center

Collaborator

Hong Kong Children's Hospital

Collaborator

Ramathibodi Hospital

Collaborator

Aga Khan University

Collaborator

Aichi Children's Health and Medical Center, Japan

Collaborator

Hospital Sultanah Aminah Johor Bahru

Collaborator

Children's Hospital of Chongqing Medical University

Collaborator

Prof IGNG Ngoerah Hospital

Collaborator

Penang Hospital, Malaysia

Collaborator

Vietnam National Children's Hospital

Collaborator

Hospital Pakar Kanak-kanak UKM

Collaborator

National University Hospital, Singapore

Collaborator

Queen Elizabeth Hospital, Hong Kong

Collaborator

Shanghai Children's Medical Center

Collaborator