Assesment of Treatment Outcomes of Aquired Aplastic Anemia in Children : A Retrospective and Prospective Cohort

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-18
SponsorAssiut University

About this trial

The goal of this observational study is to to assess of treatment Outcomes of Aquired Aplastic Anemia in children

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Children aged 1-18 years diagnosed with acquired aplastic anemia, as confirmed by bone marrow examination and fulfilling diagnostic criteria (e.g., bone marrow cellularity <25% and at least two of the following: absolute neutrophil count <500/μL, platelet count <20,000/μL, absolute reticulocyte count <60,000/μL)123.

The bone marrow biopsy should be compitable with diagnosis

Diagnosed and/or treated at Assiut University Children's Hospital between Agust 2023 and Augst 2026.

Patients with complete medical records, including diagnostic, laboratory, and treatment data

Disqualifiers

Patients with inherited bone marrow failure syndromes (e.g., Fanconi anemia, dyskeratosis congenita) as confirmed by genetic testing or family history21.

Patients with incomplete or missing essential data in their medical records.

Patients diagnosed outside the specified study period or managed primarily at other institutions.

Patinets with neoplastic or granulomatous disease involving the bone marrow, systemic lupus erythematosus, AIDS, hypersplenism or other conditions associated with pancytopenia such as myelodysplastic syndrome,and paroxysmal nocturnal hemoglobinuria.

Trial population

Children aged 1-18 years diagnosed with acquired aplastic anemia

Trial design

Design model

Cohort

Time perspective

Other

Treatments tested in this trial

Not listed

Trial groups

35 Participants
are grouped into 2 trial groups
Group A: patient diagnosed with aplastic anemia from July 2023 to sept 2025
Group B: patient diagnosed with aplastic anemia from Sept 2025 to July 2026

Trial outcomes

Primary outcomes

1

To evaluate the treatment outcomes of children diagnosed with aplastic anemia.

Time frame
July 2023-July 2026

Secondary outcomes

1

To assess response rates to various treatment modalities, including: oImmunosuppressive therapy (IST) oHematopoietic stem cell transplantation (HSCT) oSupportive care only

Time frame
July 2023_July 2026

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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