Assess the Risk of Cerebrovascular Disease

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorTang-Du Hospital

About this trial

Intracranial artery stenosis is an important cause of ischemic stroke, but the degree of intracranial artery stenosis is not completely matched with the symptoms of ischemic stroke. Asymptomatic carotid stenosis (ACS) refers to does not appear related neurological symptoms of carotid stenosis and stroke or transient ischemic attack of carotid stenosis, did not happen cerebrovascular events such as stroke, but there have been a different degree of cognitive impairment, be badly in need of development of noninvasive imaging methods, objective evaluation of the ACS group cognitive impairment, and predict the ACS risk of ischemic stroke. Therefore, this topic proposed comprehensive cognitive assessment, CTA, double modal MRI techniques, clinical and biochemical indicator detection, mathematical modeling and statistical analysis techniques, assess the ACS group and normal person the cognitive ability, the difference of NVC and local perfusion, and follow-up ACS crowd of ischemic stroke and other cardiovascular events, discuss ACS and cognitive impairment, the correlation of NVC and local perfusion abnormalities, screening of radiographic predictor of ischemic stroke, and in the follow-up of ACS population in testing the sensitivity of the series of indicators and specific degrees.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Mild stenosis group: CTA suggested carotid stenosis < 30%;

Moderate stenosis group: CTA suggested carotid stenosis of 30-69%;

Severe stenosis group: CTA indicated carotid stenosis ≥70%;

Disqualifiers

dementia, MMSE score < 21;

previous carotid stenosis related neurological symptoms or transient ischemic attack;

other craniocerebral lesions, such as craniocerebral trauma, tumor, inflammation, and complications of great vessels (cerebral infarction or cerebral malacia);

contraindications for MRI examination;

Trial population

No carotid stenosis - related neurological symptoms and transient ischemic attacks (50 patients in each group, 25 males and 25 females).

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • GE Discovery MR750 3.0t superconducting MRI

    Device

    T2WI, FLAIR, DWI, 3D BRAVO, 3D-ASL, rs-fMRI, DKI sequences to exclude other organic lesions

Treatment groups

100 Participants
are divided into 1 treatment group
Group A: No related neurological symptoms and transient ischemic attack1 intervention

Trial outcomes

Primary outcomes

1

Dynamic change and correlation analysis of multi-dimensional features of ACS degree and cognitive impairment

The Montreal cognitive assessment (MoCA) scale was used to evaluate the differences in cognitive function between ACS and the healthy control group in different dimensions, and the horizontal correlation analysis between ACS and cognitive impairment was conducted according to the dimensions of cognitive impairment and the degree of ACS.

Time frame
2020.01

Secondary outcomes

Other outcomes

Sponsors and contacts

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