Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40-89
SponsorNational University of Singapore
About this trial
This study examines whether routine treatment with semaglutide or tirzepatide, prescribed with lifestyle coaching in a real-world weight-management program, is associated with changes in biological age measured by the LinAge2 clinical aging clock over 6 months.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adults aged 40-89 years, who are newly enrolled in the NOVI OP+ weight management program.
BMI of ≥ 30 kg/m2 (obesity); OR
BMI of ≥ 27 kg/m2 to < 30 kg/m2 (overweight) in the presence of at least one weight-related comorbid condition e.g. dysglycemia (prediabetes or type 2 diabetes mellitus), hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease.
Disqualifiers
Pregnancy or lactation.
Non-ambulatory status, total blindness, complete hearing loss, or inability to speak.
Medical history of, or self-reported, psychiatric illness, congenital or irreversible neurodegenerative diseases, cognitive impairment, or eating disorders that may affect adherence or assessment outcomes.
On GLP-1 RA, sulfonylurea or insulin medications for the past 3 months.
Trial population
Adults aged 40-89 years who are overweight or obese and newly enrolled in the NOVI Health weight management program in Singapore. Participants are selected from routine clinical practice at the NOVI Health clinic.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not applicable. This is an observational study.
Other interventionNot applicable. This is an observational study.
Treatment groups
440 Participants
are divided into 1 treatment groupGroup A: NOVI Health weight management cohort1 intervention
Trial outcomes
Primary outcomes
1
LinAge2 Biological Age
The primary outcome of this study is to determine the change in LinAge2 biological age estimates in response to the NOVI Health weight management program, which comprises GLP-1 RA therapy alongside personalized diet and physical activity interventions.
Time frame
Baseline and 6 monthsSecondary outcomes
1
Change in Body Composition: Body Weight
Body weight measured in kilograms (kg); outcome is change from baseline to 6 months.
Time frame
Baseline and 6 months2
Change in Body Composition: Body Mass Index (BMI)
BMI calculated as weight (kg) divided by height (m²), reported in kg/m².
Time frame
Baseline and 6 months3
Change in Body Composition: Waist Circumference
Waist circumference measured in centimeters (cm) using a measuring tape
Time frame
Baseline and 6 months4
Change in Body Composition: Hip Circumference
Waist circumference measured in centimeters (cm) using a measuring tape
Time frame
Baseline and 6 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
National University of Singapore
Lead sponsor
T3 Health PTE LTD
Collaborator
Source ClinicalTrials.gov
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