Assessing the Association Between WBCT PFJ Morphological Metrics and Knee Symptoms

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Kansas Medical Center

About this trial

Patellofemoral joint (PFJ) pain is a common, often chronic, aching pain behind or around the kneecap, frequently called "runner's knee". It occurs when the kneecap does not glide smoothly over the thigh bone, often due to muscle weakness or overuse. It makes sitting for long periods, climbing stairs, or kneeling painful.

Symptomatic knee osteoarthritis (OA) is a common, long-term condition where the protective cartilage in the knee joint wears away, causing the bones to rub together, leading to daily pain and stiffness. In simple terms, it is a "wear-and-tear" disease of the entire joint that makes walking, climbing stairs, or bending the knee difficult.

The PFJ is where the patella (kneecap) meets the femoral trochlea (front part of the lower thigh bone) at the front of the knee. Patellar tracking refers to the movement of the patella that begins to engage in the distal femoral trochlear groove (smooth, U-shaped groove at the bottom of the thigh bone).

By doing this study, we hope to advance clinical knowledge of the PTJ features in a more natural position by using weight-bearing computed tomography (WBCT) images while the leg is straight and slightly bent. Determining links between specific knee symptoms and the PTJ structure on WBCT images could enable providers to effectively target the underlying causes and to develop targeted treatments.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18

Knee pain, falling into either of the two groups, i.e., PFJ pain (pain only in the anterior region of the knee) or symptomatic knee OA (pain in any other area of the knee, including the anterior region)

Disqualifiers

Bilateral total knee arthroplasty

Pregnant

Unable to stand safely for 2 minutes with support

Any condition that the investigator identifies as inappropriate for participation (e.g., unable to participant in consent process, unsafe to stand on WBCT platform, etc.)

Trial population

Voluntary participants who consented to be contacted for research

Trial design

Design model

Other

Time perspective

Cross-sectional

Treatments tested in this trial

  • WBCT

    Radiation

    Images of the knee will be acquired using a WBCT, which provides a three-dimensional view of the patellofemoral joint in a loaded configuration.

Treatment groups

36 Participants
are divided into 2 treatment groups
Group A: PFJ pain1 intervention
Group B: Symptomatic knee OA1 intervention

Trial outcomes

Primary outcomes

1

TT-TG

Tibial Tuberosity - Trochlear Grove (TT-TG) will be measured on 3D WBCT knee images acquired at 0° and 20±5° of knee flexion.

Time frame
From enrollment to end of study (1 day)
2

reTRF

Relative external tibiofemoral rotation (reTFR) will be measured on 3D WBCT knee images acquired at 0° and 20±5° of knee flexion.

Time frame
From enrollment to end of study (1 day)
3

Congruence Angle

Congruence angle will be measured on 3D WBCT knee images acquired at 20±5° of knee flexion.

Time frame
From enrollment to end of study (1 day)

Secondary outcomes

1

PTA

Patellar tilt angle (PTA) will be measured on 3D WBCT knee images acquired at 0° and 20±5° of knee flexion.

Time frame
From enrollment to end of study (1 day)
2

Bisect Offset

Bisect offset will be measured on 3D WBCT knee images acquired at 0° of knee flexion.

Time frame
From enrollment to end of study (1 day)
3

Patellar Height

Patellar height will be measured on 3D WBCT knee images acquired at 0° and 20±5° of knee flexion.

Time frame
From enrollment to end of study (1 day)

Other outcomes

1

Patellar tilt

The angle between the line connecting the most posterior points of femoral condyles and the patella axis through the medial and lateral borders will be measured on WBCT acquired at 0° of knee flexion.

Time frame
From enrollment to end of study (1 day)

Sponsors and contacts

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