Assessing the Effect of an Antioxidant-Rich Diet on Metabolic Syndrome Risk Using the Dietary Antioxidant Index

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of Veterinary and Animal Sciences, Lahore - Pakistan

About this trial

Metabolic syndrome (MetS) is a cluster of metabolic disorders characterized by elevated levels of blood glucose, hypertension, dyslipidemia, and abdominal obesity. Globally, it is a major public health concern. International studies have linked higher Dietary Antioxidant Index with reduced risk of MetS, as antioxidants play a role in lowering the risk of MetS by reducing oxidative stress, a key contributor to its pathophysiology. Exploring this link in Pakistan can provide valuable insights for dietary strategies to reduce the risk of MetS.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged 18-45 years

Metabolic syndrome risk (abdominal obesity & elevated BP as per NCEP ATP III criteria).

Low fruit & veg intake (<5 serv./day) as per WHO.

Willing to follow an intervention

Disqualifiers

Individuals < 18 years or > 45 years

Not at risk of metabolic syndrome.

Adequate intake of fruits & veg (≥ 5 serv./day) as per WHO

Not willing

Trial design

Design model

Single group

Treatments tested in this trial

  • Antioxidant-Focused Diet Intervention

    Other intervention

    This intervention specifically targets the Dietary Antioxidant Index (DAI) by increasing consumption of antioxidant-rich foods such as fruits, vegetables, whole grains, and legumes, while limiting pro-oxidant and ultra-processed foods. Unlike general healthy diet interventions, this study focuses on quantifiable antioxidant intake and its direct association with metabolic syndrome risk in urban adults.

Treatment groups

55 Participants
are divided into 1 treatment group
Group A: Dietary Antioxidant Index-Based Dietary Intervention ArmExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in Dietary Antioxidant Index (DAI)

DAI will be calculated from 24-hour dietary recalls to quantify total antioxidant intake. The primary objective is to assess whether the antioxidant-rich diet increases DAI in participants.

Time frame
Baseline and after 12 weeks of intervention
2

Change in Metabolic Syndrome Risk Score

A composite metabolic syndrome risk score will be calculated by summing standardized z-scores of waist circumference (cm), fasting blood glucose (mg/dL), systolic blood pressure (mmHg), triglycerides (mg/dL), and inversely weighted HDL-cholesterol (mg/dL) to generate a single continuous measure of overall metabolic syndrome risk.

Time frame
Baseline and after 12 weeks of intervention

Secondary outcomes

1

Change in Body Composition

Body composition, including body fat percentage and skeletal muscle mass, will be assessed using InBody analyzer to evaluate changes in body composition.

Time frame
Baseline and after 12 weeks of intervention

Other outcomes

Sponsors and contacts

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