About this trial
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:
* Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways?
Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics)
Participants will:
* Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.
Eligibility criteria
Qualifiers
CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.
Disqualifiers
History or presence of vascular disease that may affect cognitive function
History or presence of stroke within the past 1 year
Recent transient ischemic attack (TIA) within the past 180 days
History of severe, clinically significant CNS trauma
Trial design
Treatments tested in this trial
- EVOO-phenolics dietary supplement
- Placebo