Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50-70
SponsorAugusta University

About this trial

The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:

* Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways?

Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics)

Participants will:

* Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.

Eligibility criteria

Qualifiers

CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.

Disqualifiers

History or presence of vascular disease that may affect cognitive function

History or presence of stroke within the past 1 year

Recent transient ischemic attack (TIA) within the past 180 days

History of severe, clinically significant CNS trauma

Trial design

Treatments tested in this trial

  • EVOO-phenolics dietary supplement
  • Placebo

Treatment groups

20 Participants
are divided into 2 treatment groups

Sponsors and collaborators