Assessment of a Multimodal Analgesia for Enhanced Recovery After Cardiac Surgery

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-60
SponsorAssiut University

About this trial

This work aims to assess the analgesic efficacies of transversus thoracic muscle plane block (TTPB) and transversus thoracic muscle plane block (TTPB) for open cardiac surgeries

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 40 to 60 years.

Both sexes.

American Society of Anesthesiology (ASA) physical status II-III.

Body mass index (BMI) < 35 kg/m2.

Disqualifiers

Valve replacement procedures.

Emergency operations.

Redo surgeries.

Minimally invasive approaches.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Pecto-intercostal fascial block

    Other intervention

    Patients will receive pecto-intercostal fascial block intraoperatively (20 ml of bupivacaine 0.25% + 1 ml dexamethasone 8 mg).

  • Transversus thoracic muscle plane block

    Other intervention

    Patients will receive transversus thoracic muscle plane block was performed intraoperatively (20 ml of bupivacaine 0.25% + 1 ml dexamethasone 8 mg).

  • Sham (No Treatment)

    Other intervention

    Patients will receive bilateral superficial needle puncture at a location like transversus thoracic muscle plane block without any solution injected. Only 25 saline will be injected superficially.

Treatment groups

90 Participants
are divided into 3 treatment groups
Group A: Group PIFBExperimental treatment 1 intervention
Group B: Group TTPBExperimental treatment 1 intervention
Group C: Control GroupSham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Total amount analgesic requirement

In cases where rescue analgesia is required \[numerical rating scale (NRS) ≥4\], intravenous Nalbuphine 0.1 mg/kg will be given.

Time frame
24 hours postoperatively

Secondary outcomes

1

Degree of pain

Degree of pain will be assessed using Numerical rating scale (NRS) from 0 (no pain) to 10 (worst severe pain). NRS will be measured at 2h, 4h, 8h, 16h and 24h after surgery.

Time frame
24 hours postoperatively
2

The number of patients required rescue analgesia

The number of patients requires rescue analgesic will be recorded at 0, 3, 6, 12, 18, and 24 hours after extubation.

Time frame
24 hours postoperatively
3

Postoperative nausea and vomiting (PONV)

The patients will be verbally evaluated according to a descriptive five-point postoperative nausea and vomiting (PONV) scale at 0, 3, 6, 12, 18, and 24 hours after the extubation. If a score of 3 or more is registered, ondansetron 4 mg IV will be administered and repeated after 8 hours if required. The PONV scale is 0 = no nausea; 1 = slight nausea; 2 = moderate nausea; 3 = vomiting once; and 4 = vomiting more than once.

Time frame
24 hours postoperatively
4

Time to extubation

After the operation, the time until the patient is extubated will be recorded.

Time frame
24 hours postoperatively

Other outcomes

Sponsors and contacts

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