Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation

ConditionLiver Transplantation

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorUniversity Hospital, Toulouse

About this trial

Liver transplantation carries a substantial risk of bleeding, making precise haemostasis control essential, although assessing coagulation remains challenging. Quantra, a bedside viscoelastic testing device using sonorheometric methods, offers an innovative approach to guiding haemostatic management during surgery. The study aims to determine whether a Quantra-guided transfusion can reduce transfusion and bleeding during liver transplantation when compared to a conventional transfusion approach.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged 18 years or older

Patient with ESLD undergoing liver transplantation

Individuals affiliated with or beneficiaries of a social security scheme

Free and informed written consent obtained in writing from the patient, or where applicable from the trusted person/family member/close relative

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

Transfusion algorithm based on Quantra®
Biological/Vaccine
In addition to routine coagulation tests, a Quantra Qstat® analysis will be performed at baseline (before incision), at the end of native liver dissection, and after unclamping of the venous anastomoses. In the event of bleeding, additional Quantra Qstat® analyses may be conducted until bleeding control is achieved. Transfusion and administration of blood-derived medications will be guided by the results of the Quantra Qstat® analyses.
Conventional transfusion algorithm
Biological/Vaccine
Transfusion and blood-derived medications will be guided by the results of routine coagulation tests.

Treatment groups

56 Participants

are divided into 2 treatment groups

Group A: Transfusion algorithm based on Quantra®Experimental treatment 1 intervention

Group B: Conventional transfusion algorithmActive comparator 1 intervention

Trial outcomes

Primary outcomes

Fresh Frozen Plasma (FFP) transfusion during liver transplantation surgery

Number of FFP transfused intraoperatively during liver transplantation surgery.

Time frame

Conducted during surgery

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Toulouse

Lead sponsor

Source ClinicalTrials.gov

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