Assessment of Serum Catestatin Level in Acne Vulgaris Patients

ConditionAcne Vulgaris

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-40

SponsorAswan University

About this trial

Acne vulgaris is a persistent inflammatory condition of the pilosebaceous unit, affecting 85% of people between the ages of 12 and 24, it is regarded as one of the most common diseases in teenagers and young adults.

Catestatin, a peptide derived from chromogranin A (CgA), was first discovered in 1997 as an acute nicotinic-cholinergic antagonist. Later, it was determined that CST is a pleiotropic hormone.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy persons of both sexes with moderate and severe acne.

Disqualifiers

Pregnant and lactating women.

Immunocompromised patients.

Severe anemia.

History of chronic liver disease.

Trial design

Design model

Parallel

Treatments tested in this trial

Isotretinoin
Drug
* Measure the serum levels of catestatin in patients with moderate and severe acne vulgaris versus healthy control persons. * Evaluate the effect of oral isotretinoin treatment on serum catestatin levels in patients with moderate and severe acne vulgaris.

Treatment groups

60 Participants

are divided into 2 treatment groups

Group A: Group I (Study Group)Active comparator 1 intervention

Group B: Group II (Control Group)Placebo comparator 1 intervention

Trial outcomes

Primary outcomes

Evalaute serum level of Catestatin in acne patient

Assessment of clinical improvement according to:(8) G4(excellent:100% reduction) G3(good:75-99% reduction) G2(moderate: 50-74% reduction) G1(insufficient :1-49% reduction) G0(unchanged) G-1(worse)

Time frame

12 weeks

Evalaute the effect of treatment with systemic isotretinon

Evaluate the effect of treatment with systemic isotretinon therapy (0.5 mg/kg/day, up to 40 mg daily) on the level of serum Catestatin on the Participants whom suffering from Acne Vulgaris whether moderate or severe.

Time frame

12 weeks

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Aswan University

Lead sponsor

Source ClinicalTrials.gov

Apply now