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Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates

ConditionVasovagal Syncope
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity of Calgary

About this trial

The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments. In order to safely manipulate the HR, the investigators will study patients with permanent pacemakers in whom heart rate manipulation can be done in a safe and non-invasive manner.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18-70 years (inclusive)

Implanted permanent pacemaker or implanted defibrillator capable of atrial and ventricular pacing

LV ejection fraction >50%

Disqualifiers

Unable or unwilling to provide informed consent

Clinical need for a cardiac resynchronization device

Trial design

Design model

Single group

Treatments tested in this trial

  • Pacing

    Device

    Assess the non-invasively determined stroke volume and cardiac output response at different paced heart rates in patients with a cardiac pacemaker or implanted defibrillator with preserved ejection fractions (LVEF≥50%)

Treatment groups

25 Participants
are divided into 1 treatment group
Group A: Stroke volume and cardiac outputExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in cardiac output while atrial pacing at lower and higher rates while supine

Change in cardiac output (CO) when atrial pacing at 80 bpm \& 120 bpm while supine. CO = HR x Stroke volume (SV)

Time frame
1 day

Secondary outcomes

1

Change in cardiac output at lower and higher ventricular (VVI) paced rates while supine

Change in Cardiac output at ventricular (VVI) paced rates when it is lower (50-70 bpm) and higher (130 bpm) while supine

Time frame
1 day
2

Change of cardiac output at lower and higher atrial (AAI) paced rates while supine versus while upright

Change of cardiac output at lower and higher atrial (AAI) paced rates while supine versus while upright at different paced rates

Time frame
1 day
3

Change of cardiac output at lower and higher ventricular (VVI) paced rates while supine versus while upright

Change of cardiac output at lower and higher ventricular (VVI) paced rates while supine versus while upright at different paced rates

Time frame
1 day
4

Change in stroke volume at lower and higher atrial paced rates while tilted up

Change in stroke volume at lower (50-70 bpm) vs. higher (130 bpm) atrial paced rates while tilted up

Time frame
1 day

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Calgary

Lead sponsor

Source ClinicalTrials.gov
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