Health TrialsbyHealthPanel

Assessment of the Relationship Between Cerebral Blood Flow and Heart Rate

ConditionsCerebrovascular CirculationPhysiology
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity of Calgary

About this trial

The investigators will seek to determine the relationship between heart rate and middle cerebral artery (MCA) cerebral blood flow (CBF), as well as better understand the hemodynamic determinants of MCA CBF velocity. In order to manipulate heart rate, the investigators will recruit patients already scheduled for clinically indicated elective electrophysiological studies, where temporary pacing catheters placed in the right atrium can be used to artificially pace the heart at controlled rates. MCA CBF will be measured by transcranial Doppler ultrasound.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Male or female

Age 18-70 years, inclusive

Scheduled for clinically indicated elective electrophysiological studies where temporary pacing catheters are being placed in the right atrium

Left ventricular ejection fraction ≥50%

Disqualifiers

Unable or unwilling to provide informed consent

Other factors which in the investigator's opinion would prevent the participant from completing the protocol

Trial design

Design model

Single group

Treatments tested in this trial

  • Electrophysiological Pacing

    Other intervention

    Assess the MCA CBF velocity response at different paced heart rates.

Treatment groups

20 Participants
are divided into 1 treatment group
Group A: Patients Scheduled for Elective Electrophysiological StudyExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Change in MCA CBF velocity in response to high right atrial pacing at 400 ms (150 bpm) relative to baseline while in the supine position

Compare the MCA CBF velocity at the participant's own baseline sinus rhythm (\<100 bpm) and during pacing at 400 ms (150 bpm)

Time frame
After 1 minute of pacing at 400 ms (150 bpm)

Secondary outcomes

1

Change in MCA CBF velocity in response to high right atrial pacing at 600 ms (100 bpm) relative to baseline while in the supine position

Compare the MCA CBF velocity at the participant's own baseline sinus rhythm (\<100 bpm) and during pacing at 600 ms (100 bpm)

Time frame
After 1 minute of pacing at 600 ms (100 bpm)
2

Change in MCA CBF velocity in response to high right atrial pacing at 350 ms (171 bpm) relative to baseline while in the supine position

Compare the MCA CBF velocity at the participant's own baseline sinus rhythm (\<100 bpm) and during pacing at 350 ms (171 bpm)

Time frame
After 1 minute of pacing at 350 ms (171 bpm)
3

Change in MCA CBF velocity in response to high right atrial pacing at 400 ms (150 bpm) relative to pacing at the lowest rate (100 bpm) while in the supine position

Compare the MCA CBF velocity during pacing at 600 ms (100 bpm) and during pacing at 400 ms (150 bpm)

Time frame
10 minute electrophysiological pacing protocol
4

Change in MCA CBF velocity in response to high right atrial pacing at 350 ms (171 bpm) relative to pacing at the lowest rate (100 bpm) while in the supine position

Compare the MCA CBF velocity during pacing at 600 ms (100 bpm) and during pacing at 350 ms (171 bpm)

Time frame
10 minute electrophysiological pacing protocol

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Calgary

Lead sponsor

Source ClinicalTrials.gov
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