This observational, cross-sectional case-control study evaluates obsessive-compulsive symptoms among adults with substance use disorder compared with a demographically similar control group without substance use disorder. Patients aged 18-50 years attending the addiction management inpatient and outpatient services at Assiut University Hospital, and healthy controls recruited from relatives, friends, and hospital staff, will complete structured clinical interviews, the Yale-Brown Obsessive-Compulsive Scale, and other standardized scales for psychiatric symptoms, cognition, and quality of life. The main objective is to estimate the prevalence and severity of obsessive-compulsive symptoms in substance use disorder and examine their associations with sociodemographic and clinical factors, addiction severity, and quality of life in the recovery stage.
Willing and able to provide informed consent and participate in the study assessments.
For the case group: patients with a diagnosed substance use disorder (single or polysubstance) attending the inpatient or outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital.
For the control group: relatives, friends, or hospital workers without substance use disorder, recruited through invitation or advertisement.
Severe psychiatric comorbidities such as schizophrenia, major depressive disorder, bipolar disorder, or anorexia nervosa.
Current intoxication or acute withdrawal state from substances.
Severe medical conditions including end-stage renal disease, metastatic cancer, severe heart failure, or chronic obstructive pulmonary disease.
Severe cognitive impairment
Adults aged 18-50 years attending the inpatient and outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital, with a diagnosed substance use disorder, and a comparison group of relatives, friends, or hospital workers without substance use disorder. Participants of both sexes who provide informed consent will be assessed once during the recovery (non-intoxication, non-withdrawal) stage using structured clinical interviews, standardized scales for obsessive-compulsive symptoms, psychiatric comorbidity, cognition, and global psychopathology, as well as urine toxicology.
Case-control
Cross-sectional
Not listed
Severity of Obsessive-Compulsive Symptoms in Patients with Substance Use Disorder Measured by Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Total Score
Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score assessing severity of obsessive-compulsive symptoms in patients with substance use disorder. Scale ranges from 0 to 40 points, where higher scores indicate greater severity, assessed once at study enrollment during recovery stage defined as non-intoxication and non-withdrawal.
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