Association Between 4D MRI Parameters and the Clinical Characteristics and Prognosis of Major Chronic Diseases
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age19+
SponsorUlsan University Hospital
About this trial
Cancer and cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Advanced imaging techniques such as 4D magnetic resonance imaging (MRI) enable quantitative assessment of hemodynamic and functional parameters beyond conventional imaging. The aim of this study is to evaluate the association between 4D MRI derived parameters and the occurrence, severity, and prognosis of major chronic diseases, and to explore their potential role as imaging biomarkers.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 19 years and older undergoing clinically indicated Cardiac MRI at Ulsan University Hospital
Participants who undergo an additional 4D MRI sequence during the same imaging session
Participants who are able to understand the study and provide written informed consent
Disqualifiers
Individuals aged < 19 years
Individuals with cognitive impairment or communication difficulties unable to provide informed consent
Poor-quality MRI images that are not suitable for analysis
Individuals deemed inappropriate for study participation by the investigator
Trial population
Adult patients aged 19 years and older undergoing clinically indicated cardiac MRI at Ulsan University Hospital (Ulsan, South Korea) will be included in the study population. Individuals who provide written informed consent and undergo an additional 4D MRI sequence during the same imaging session will be enrolled in this prospective observational registry.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
1,000 Participants
are grouped into 1 trial groupGroup A: Ulsan University Hospital, 4D MRI cohort
Trial outcomes
Primary outcomes
1
Incidence of Major Adverse Cardiovascular Events (MACE)
Incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure during the follow-up period
Time frame
up to 10 yearsSecondary outcomes
1
Peak Wall Shear Stress
peak wall shear stress measured in the ascending aorta using 4D flow MRI
Time frame
Perioperative/Periprocedural2
Blood Flow Eccentricity
Blood Flow Eccentricity assessed in the ascending aorta using 4D flow MRI
Time frame
Perioperative/PeriproceduralSponsors and contacts
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Source ClinicalTrials.gov