Association Between Exercise, Patient-Reported Outcomes, and Clinical Events in Adult Cancer Survivors
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMemorial Sloan Kettering Cancer Center
About this trial
This protocol is a retrospective study using observational data to conduct a target trial emulation to examine the association of exercise on cancer specific endpoints and other clinical outcomes in cancer survivors.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adult (≥18 years of age) patients with history of primary invasive cancer under surveillance at Memorial Sloan Kettering Cancer Center (MSK).
Completion of an exercise survey (baseline) as part of MSK Cancer Survivorship Program and completion of a historical survey in the MSK Cancer Survivorship Program 9-15 months (time th) prior reporting non-exercising status [i.e., reporting <10 metabolic equivalent-hours per week (MET-h/week)]. Patients completing an additional exercise survey between th and baseline are excluded.
No evidence of recurrent or metastatic disease in the 15 months prior to the baseline exercise assessment
Completion of all definitive primary adjuvant therapy (e.g., chemotherapy, radiotherapy, targeted therapy) at least 3 months prior to completion of the historical exercise survey in a MSK Cancer Survivorship Program. Adjuvant hormonal therapy is permitted at any time.
Disqualifiers
None
Trial population
Adult (≥18 years of age) cancer survivors under surveillance at Memorial Sloan Kettering Cancer Center (MSK) between 2011 and 2023.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Exercise
BehavioralExercise following completion of active treatment for the primary index cancer
Treatment groups
61,100 Participants
are divided into 2 treatment groupsGroup A: Arm 1: Usual Care0 interventions
Group B: Arm 2: Exercise1 intervention
Trial outcomes
Primary outcomes
1
Distant disease-free survival (DDFS)
To estimate the association of exercise vs. usual care (control) with Distant disease-free survival (DDFS) among patients following the completion of active treatment for the primary index cancer being monitored at MSK.
Time frame
5 yearsSponsors and contacts
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Source ClinicalTrials.gov