According to 2017 World Workshop of Periodontology , the level of high sensitivity C reactive protein has been assumed to increase according to the grade of periodontitis, however, specific evidence regarding this is lacking at present. Hence, measuring high sensitivity C reactive protein in serum and oral rinse samples in systemically healthy individuals with periodontitis could be potentially useful in gaining insight on the systemic burden of periodontal disease.
Patients in the age group of (18-50 years)
Presence of ≥ 20 natural teeth
Ability and willingness to give written informed consent
Patients belonging to 3 groups -periodontally healthy, stage III and stage IV grade B periodontitis, and stage III and stage IV grade C periodontitis .
• Patients with chronic inflammatory disease such as nephrotic syndrome, chronic renal failure, significant cardiovascular disease, established type 1 or type 2 diabetes mellitus, or active cancer within the past 5 years
Smokers and alcoholics
Pregnant females
Presence of xerostomia
1. Group 1: comprising of periodontally healthy individuals. 2. Group 2: comprising of individuals, diagnosed with stage III and stage IV grade B periodontitis (according to WWP 2017 classification periodontal disease ) 3. Group 3: comprising of participants, diagnosed with stage III and IV grade C periodontitis,
Other
Cross-sectional
Not listed
Evaluation of hscrp level in oral rinse samples and serum in 3 groups of systemically healthy individuals
Evaluation of hsCRP level in oral rinse samples and serum in 3 groups of systemically healthy individuals (periodontally healthy, stage III and stage IV grade B generalized periodontitis, stage III and stage IV grade C generalized periodontitis)
Correlation of Probing pocket depth (PPD)and Clinical attachment level (CAL) with level of hsCRP in oral rinse and serum samples.
Correlation of Probing pocket depth (PPD) with level of hsCRP in oral rinse and serum samples. Correlation of Clinical attachment level (CAL) with level of hsCRP in oral rinse and serum samples.
Correlation of Bleeding on probing (BOP%)
Correlation of Bleeding on probing (BOP%) with level of hsCRP in oral rinse and serum samples.
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