Association Between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorAssiut University

About this trial

Association between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged >18 years old

presented with a clinical suspicion of sleep-disordered breathing, including snoring, sleepiness and witnessed sleep apnea

Disqualifiers

Patients aged ≤18 years old

Pregnancy

Presence of malignancy

Type I DM

Trial population

* Patients with a clinical suspicion of sleep-disordered breathing will undergo overnight polysomnography and the followings indices will be recorded(apnea-hypopnea index (AHI); oxygen desaturation index (ODI); lowest arterial oxyhemoglobin saturation during sleep(LaSO2); mean arterial oxyhemoglobin saturation during sleep(mean SpO2); and %sleep time in which SpO2 \< 90%.( TS90%). * Diagnosis of MAFLD will made when a patient has BMI \>25 kg/m2, T2DM or at least two metabolic risk abnormalities. * All patients will undergo data pertaining to clinical history (name, age, sex, residence, occupation, co-morbidities… diabetes, hyperlipidemia, hypertension, ischemic heart disease, special habits; such as alcohol intake and smoking). * Four anthropometric measurements will be obtained (height, weight, body mass index, waist circumference (WC)). * Blood samples will be collected for doing liver function tests, lipid profile, CBC, HbA1c.

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Correlation Between Apnea-Hypopnea Index and MASLD

To assess the correlation between the Apnea-Hypopnea Index (AHI), measured by overnight polysomnography (events/hour), and hepatic steatosis measured by FibroScan with Controlled Attenuation Parameter (CAP), reported in decibels per meter (dB/m).

Time frame
At baseline

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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