Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorYongquan Shi
About this trial
The objective of this clinical trial is to explore the correlation between the level of microplastic exposure and the risk of gastric mucosal carcinogenesis, and to evaluate the strength of its effect as an independent risk factor. The main questions it aims to answer include: Does the level of microplastic exposure increase the risk of gastric mucosal carcinogenesis? Can the correlation between the level of microplastic exposure and gastric mucosal carcinogenesis, as well as the sources of high - risk microplastic exposure, be explored through a questionnaire on external microplastic exposure? Researchers will complete a design structured questionnaire and ask participants to fill it out carefully and truthfully to determine whether the level of microplastic exposure increases the risk of gastric mucosal carcinogenesis.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Aged between 18 and 75 years old, gender is not restricted
Having a clear diagnosis result within the recent three months and being diagnosed with chronic non - atrophic gastritis, precancerous lesions of gastric cancer, or gastric cancer for the first time
Have clear Helicobacter pylori (Hp) test results
Be in normal mental state and able to independently complete the questionnaire survey
Disqualifiers
Patients with a history of malignant tumors in other parts
Patients who have previously undergone upper gastrointestinal surgery, chemotherapy, or radiotherapy
Patients with severe diseases of major organs such as the heart, lungs liver, and kidneys
Patients who are currently receiving psychological intervention or taking psychiatric drugs
Trial population
Patients were enrolled from a single center, Xijing Hospital.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
450 Participants
are grouped into 3 trial groupsGroup A: Chronic non-atrophic gastritis
Group B: precancerous lesion
Group C: gastric cancer
Trial outcomes
Primary outcomes
1
Correlation between external exposure levels of microplastics and three pathological stages of gastric mucosal carcinogenesis
The investigators evaluated the correlation between external exposure to microplastics and the three pathological stages of gastric mucosal carcinogenesis based on the patients' final diagnosis results and the completed questionnaires they filled out.
Time frame
9 monthsSecondary outcomes
1
Analysis of sources of high - risk microplastic exposure
Analyze the sources of high-risk microplastic exposure by comparing the scores of each item in the questionnaires of the three groups of participants.
Time frame
9 months2
Synergistic toxicity of microplastics and Helicobacter pylori
Analyze whether microplastics synergistically promote gastric mucosal injury and increase the risk of canceration with Helicobacter pylori through interaction.
Time frame
9 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Yongquan Shi
Lead sponsor
Xijing Hospital of Digestive Diseases
Sponsor institution
Source ClinicalTrials.gov