This study will look at how well a measure called the Qmax/eGFR ratio is related to the severity of urination problems in men over the age of 40. Qmax is a test that shows how fast a person can urinate, and eGFR is a number that reflects kidney function. Men who have urinary symptoms will be asked to do a urine flow test, a blood test, and fill out a questionnaire about their symptoms and quality of life. We will study if there is a link between the Qmax/eGFR ratio and how severe their symptoms are. The results may help doctors better understand how kidney and urinary function are related in men with these problems.
Male patients aged 40 years or older presenting with lower urinary tract symptoms (LUTS)
Able to provide informed consent
Willing and able to undergo uroflowmetry and blood testing
Able to complete the IPSS questionnaire, including the QoL item
History of urological surgery (e.g., prostatectomy, bladder surgery)
Diagnosed or suspected prostate cancer
Active urinary tract infection (based on clinical symptoms or urinalysis)
Neurological conditions affecting bladder function (e.g., Parkinson's disease, spinal cord injury)
Male outpatients aged 40 years or older who present with lower urinary tract symptoms (LUTS) to the urology clinic. Participants will be evaluated during routine clinical visits and must be capable of completing symptom questionnaires and undergoing non-invasive tests such as uroflowmetry and blood sampling. The study population is drawn from a single tertiary academic medical center.
Cohort
Prospective
Not listed
Correlation Between Qmax/eGFR Ratio and Total IPSS Score
This outcome assesses the statistical correlation between the Qmax/eGFR ratio and the total International Prostate Symptom Score (IPSS). Pearson or Spearman correlation analysis will be used to evaluate the relationship between the ratio and LUTS severity.
Correlation Between Qmax/eGFR Ratio and IPSS Quality of Life Subscore
This outcome evaluates the correlation between the Qmax/eGFR ratio and the IPSS Quality of Life (QoL) subscore, aiming to assess the association between voiding/renal parameters and patient-perceived well-being.
Factors Associated With Qmax/eGFR Ratio
This outcome aims to identify clinical factors that may influence the Qmax/eGFR ratio in men over 40 with lower urinary tract symptoms. Variables to be analyzed may include age, prostate volume, voided volume, and average flow rate (Qave), among others. Multivariable analysis will be performed to explore independent associations.
Association of Clinical Variables With Qmax/eGFR Ratio
This analysis will identify clinical parameters independently associated with Qmax/eGFR ratio, including age, prostate volume, voided volume, and average flow rate (Qave). Multivariable regression models will be used to determine significant predictors.
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