Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65+
SponsorAin Shams University
About this trial
This study aims to explore the relationship between sarcopenia, fatigue, and orthostatic intolerance in older adults. It will be conducted among geriatric patients attending Ain Shams University Hospitals.
Participants aged 65 years and older will be divided into two groups: those with sarcopenia, diagnosed according to the European Working Group on Sarcopenia in Older People 2, and age- and sex-matched controls without sarcopenia. The study will compare levels of fatigue and the presence of orthostatic intolerance between the two groups.
The findings are expected to improve understanding of how sarcopenia is associated with fatigue and orthostatic symptoms in the elderly population, which may help guide better clinical assessment and management.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patients (males or females) aged 65 or above years old.
Participants who are willing to participate in the study.
Disqualifiers
Patients who are not willing to participate in the study.
patients with end organ damage (CHF NYHA III/IV), end-stage renal disease, Liver cell failure, respiratory failure.
Patients with arrhythmia or using pacemakers
patients diagnosed with parkinsonism, Diabetes mellitus, or peripheral neuropathy.
Trial population
elderly patients both males and females who are interviewed at AIN SHAMS UNIVERSITY HOSPITALS or at the hospital clinic.
Trial design
Design model
Case-control
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
90 Participants
are grouped into 2 trial groupsGroup A: cases
Group B: controls
Trial outcomes
Primary outcomes
1
Fatigue severity measured by Fatigue Severity Scale (FSS)
Difference in Fatigue Severity Scale (FSS) total score between geriatric patients with sarcopenia (defined according to European Working Group on Sarcopenia in Older People 2 criteria) and those without sarcopenia. Unit of Measure: FSS total score (range: 1-7)
Time frame
BaselineSecondary outcomes
1
Orthostatic intolerance symptoms measured by Orthostatic Hypotension Questionnaire (OHQ)
Description: Difference in Orthostatic Hypotension Questionnaire (OHQ) total score between geriatric patients with sarcopenia and those without sarcopenia. Unit of Measure: OHQ total score
Time frame
Baseline2
Orthostatic systolic blood pressure change
Description: Difference in systolic blood pressure (mmHg) upon standing at 1, 3, 5, and 10 minutes between geriatric patients with sarcopenia and those without sarcopenia. Unit of Measure: mmHg
Time frame
Baseline (during orthostatic assessment)3
Orthostatic diastolic blood pressure change
Description: Difference in diastolic blood pressure (mmHg) upon standing at 1, 3, 5, and 10 minutes between geriatric patients with sarcopenia and those without sarcopenia. Unit of Measure: mmHg
Time frame
Baseline (during orthostatic assessment)4
Orthostatic heart rate change
Description: Difference in heart rate (beats per minute) upon standing at 1, 3, 5, and 10 minutes between geriatric patients with sarcopenia and those without sarcopenia. Unit of Measure: beats per minute
Time frame
Baseline (during orthostatic assessment)Sponsors and contacts
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Source ClinicalTrials.gov
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