A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical pregnancy in an Asian population.
HRT-FET cycles performed during the prespecified retrospective study period
Women aged 18 to <42 years at the time of embryo transfer
BMI <30 kg/m²
Transfer of at least one good-quality embryo
Severe or uncontrolled endocrine disorders documented at the time of treatment (e.g., thyroid dysfunction or premature ovarian insufficiency)
Untreated severe uterine factors likely to impair implantation (e.g., severe endometriosis, large or subendometrial fibroids, intrauterine adhesions, or endometrial polyps)
Missing or implausible key exposure data after source-data verification
All eligible HRT-FET cycles performed at the Assisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology
Cohort
Other
data collection
Other interventionserum progesterone levels on embryo transfer day and clinical pregnancy
Clinical pregnancy rate
To compare the clinical pregnancy rate across prespecified serum progesterone categories on the day of embryo transfer and to estimate the association between progesterone level and clinical pregnancy.
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