About this trial
The aim of the VeMic study is to explore if venous congestion is linked with microcirculatory impairment in elective cardiac surgery patients in the postoperative ICU stay.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥ 18 years
Elective or urgent (need for definitive procedure during hospitalisation, but not emergency intervention) cardiac surgery
Disqualifiers
Age < 18 years
Pregnant women
Known severe chronic kidney disease (estimated glomerular filtration rate <15 mL/min per 1.73 m2 or dialysis)
Renal or liver transplantation
Trial population
Patients presenting for elective or urgent cardiac surgery. Urgent patients are defined as patients who have not been electively admitted for operation but who require intervention or surgery on the current admission for medical reasons. These patients cannot be sent home without a definitive procedure but do not require immediate emergency surgery.
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Difference in red blood cell velocity: concested vs non-congested
Difference in red blood cell velocity (RBCv) between patients grouped as congested (Vexus score of 2 and 3) vs. non-congested (Vexus score of 0 and 1).
Difference in total vessel density: concested vs non-congested
Difference in total vessel density (TVD) between patients grouped as congested (Vexus score of 2 and 3) vs. non-congested (Vexus score of 0 and 1).
Difference in red blood cell velocity: physiologic femoral vein flow vs. pulsatile pattern
Difference in red blood cell velocity (RBCv) between patients with a physiologic femoral vein flow vs. pulsatile pattern
Difference in total vessel density between patients with a physiologic femoral vein flow vs. pulsatile pattern
Difference in total vessel density (TVD) between patients with a physiologic femoral vein flow vs. pulsatile pattern
Secondary outcomes
Difference in RBCv between patients with different Vexus scores
Difference in RBCv between patients with a Vexus score of 0 vs. 1 vs. 2 vs. 3
Difference inTVD between patients with different Vexus scores
Difference inTVD between patients with a Vexus score of 0 vs. 1 vs. 2 vs. 3
Difference in microcirculatory reserve capacity: congested non-congested
Difference in microcirculatory reserve capacity between patients grouped as congested (Vexus score of 2 and 3) vs. non-congested (Vexus score of 0 and 1)
Difference in microcirculatory reserve capacity: physiologic femoral vein flow vs. pulsatile patern
Difference in microcirculatory reserve capacity between patients with a physiologic femoral vein flow vs. pulsatile patern
Sponsors and contacts
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