Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital, Basel, Switzerland

About this trial

The aim of the VeMic study is to explore if venous congestion is linked with microcirculatory impairment in elective cardiac surgery patients in the postoperative ICU stay.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years

Elective or urgent (need for definitive procedure during hospitalisation, but not emergency intervention) cardiac surgery

Disqualifiers

Age < 18 years

Pregnant women

Known severe chronic kidney disease (estimated glomerular filtration rate <15 mL/min per 1.73 m2 or dialysis)

Renal or liver transplantation

Trial population

Patients presenting for elective or urgent cardiac surgery. Urgent patients are defined as patients who have not been electively admitted for operation but who require intervention or surgery on the current admission for medical reasons. These patients cannot be sent home without a definitive procedure but do not require immediate emergency surgery.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Difference in red blood cell velocity: concested vs non-congested

Difference in red blood cell velocity (RBCv) between patients grouped as congested (Vexus score of 2 and 3) vs. non-congested (Vexus score of 0 and 1).

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1
2

Difference in total vessel density: concested vs non-congested

Difference in total vessel density (TVD) between patients grouped as congested (Vexus score of 2 and 3) vs. non-congested (Vexus score of 0 and 1).

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1
3

Difference in red blood cell velocity: physiologic femoral vein flow vs. pulsatile pattern

Difference in red blood cell velocity (RBCv) between patients with a physiologic femoral vein flow vs. pulsatile pattern

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1
4

Difference in total vessel density between patients with a physiologic femoral vein flow vs. pulsatile pattern

Difference in total vessel density (TVD) between patients with a physiologic femoral vein flow vs. pulsatile pattern

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1

Secondary outcomes

1

Difference in RBCv between patients with different Vexus scores

Difference in RBCv between patients with a Vexus score of 0 vs. 1 vs. 2 vs. 3

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1
2

Difference inTVD between patients with different Vexus scores

Difference inTVD between patients with a Vexus score of 0 vs. 1 vs. 2 vs. 3

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1
3

Difference in microcirculatory reserve capacity: congested non-congested

Difference in microcirculatory reserve capacity between patients grouped as congested (Vexus score of 2 and 3) vs. non-congested (Vexus score of 0 and 1)

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1
4

Difference in microcirculatory reserve capacity: physiologic femoral vein flow vs. pulsatile patern

Difference in microcirculatory reserve capacity between patients with a physiologic femoral vein flow vs. pulsatile patern

Time frame
3 measurements:T0 prior surgery, T1 first post-operative day, T2 6 hours after T1

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.