Atrial Strain in Septic Shock

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age: >18 years

Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)

TTE performed as part of medical management

No objection to data usage

Disqualifiers

Pregnancy

Moderate to severe valvular regurgitation/stenosis (>grade 2)

Ventricular or supraventricular tachyarrhythmia (HR >140 bpm) at the time of TTE

Poor echogenicity preventing LAS measurement

Trial population

Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

variation of LASr between ECOPAC and UWS

Agreement of LAS Reservoir Phase (LASr) measurement in manual mode between ECHOPAC and UWS

Time frame
1 year

Secondary outcomes

1

variation of LAScd between ECHOPAC and UWS

Comparison of LAS Conduit (LAScd) measurements in manual mode between ECHOPAC and UWS

Time frame
1 year
2

variation of LASct between ECHOPAC and UWS

Comparison of LAS Conduit (LAScd) and Contraction (LASct) measurements in manual mode between ECHOPAC and UWS

Time frame
1 year
3

Comparison of LASr measurements in apical 2-chamber views

Comparison of LASr measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS

Time frame
1 year
4

Comparison of LAScd measurements in apical 2-chamber views

Comparison of LAScd measurements in apical 2-chamber views in manual mode between ECHOPAC and UWS

Time frame
1 year

Other outcomes

Sponsors and contacts

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Centre Hospitalier Universitaire, Amiens

Lead sponsor

Henri Mondor University Hospital

Collaborator