Auditory Localization in Schizophrenia
ConditionAuditory Perception
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorHôpital le Vinatier
About this trial
Auditory sound localization is the ability to identify the position of a sound source in space. It is defined into 3 dimensions: by its position in azimuth, elevation and distance. If it is difficult to localize a sound source, it is possible to remove the localization ambiguity by interacting with the environment, in particular by changing one's position in relation to the source (e.g. by changing the orientation of the head).
Patients with schizophrenia have difficulties to localize and discriminate sounds in space but it is still poorly explored.
Additionally, deficits in auditory localization could underlie difficulties in source-monitoring (i.e., distinguish the source/origin of the information) reported in schizophrenia or deficits in auditory externalization (i.e., perception of sound outside the head).
Furthermore, schizophrenia is characterized by cerebral abnormalities in the auditory cortex, manifesting as auditory processing disorders at different stages of the pathology. Auditory localization may therefore be impaired from the onset of a first psychotic episode (FEP). This early phase of the disease is also referred to as the "critical" period, as the chances of remission are highest and the response to treatment is best. However, the three-dimensional aspect of auditory perception and the behavioral exploration strategies used to localize a sound in the early stages of schizophrenia are still little studied.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Informed of the study and having signed the consent form
With normal vision (with or without correction)
Able to understand the experimental instructions
Affiliated to the social security system
Disqualifiers
Patients with a DSM-5 diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder or brief psychotic disorder
Early intervention for first psychotic episodes
Trial design
Design model
Parallel
Treatments tested in this trial
cognitive experiments' session
BehavioralThe aim of this unique session of cognitive experiments is to study the auditory localization performance in patients with a first episode of psychosis. Results of this Arm 1 will be compared to those of Arm 2.
Treatment groups
60 Participants
are divided into 2 treatment groupsGroup A: Patient group with a first episode psychosisExperimental treatment 1 intervention
Group B: Healthy control subjectsActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Auditory localization performance in virtual reality
an auditory localization task in virtual reality was design for this study. Sounds are presented in different localization on the horizontal and vertical planes. Participants performed two blocks (noise, silent background) divided into two conditions (localization with the fixed head or with the possibility of moving the head). Participants have to determine the localization of sound in space. The main outcome will be the perception performance corresponding to the directionality error (2Dd error in cm) in relation to the sound source.
Time frame
BaselineSecondary outcomes
1
The impact of head movements on auditory localization performance
an auditory localization task in virtual reality was design for this study. Participants have to determine the localization of sounds in two different conditions: fixed head or with the possibility of moving the head. The main outcome will be the perception performance corresponding to the directionality error (2Dd error in cm) in the two different conditions.
Time frame
Baseline2
The impact of background noise on auditory localization performance
an auditory localization task in virtual reality was design for this study. Participants have to determine the localization of sounds in two different blocks: silent and noisy background. The main outcome will be the perception performance corresponding to the directionality error (2Dd error in cm) in the two different blocks.
Time frame
Baseline3
Source-monitoring performance
A computerized source memory task was designed for this study to assess the reality-monitoring (distinguishing real source and imagined source) and et internal source-monitoring (distinguishing two internal sources). The rate of correct responses and inversions are the outcome.
Time frame
Baseline4
Performance on auditory externalization
computerized auditory externalization task. Nonverbal sounds are presented, the azimuth is varied in order to create the impression of the sound coming either from inside or outside the head. Subjects have to determine whether the nonverbal burst was perceived as coming from inside or outside their head. The rate of correct responses (inside/outside) is the outcome.
Time frame
BaselineSponsors and contacts
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Source ClinicalTrials.gov
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