Health TrialsbyHealthPanel

Autogenous Tooth Transplantation With Instrumentally Simulated Open Apex and Platelet-Rich Fibrin

ConditionsTooth LossTooth DiseasesReimplant; Complications
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age10-80
SponsorUniversity of Bari Aldo Moro

About this trial

Autogenous tooth transplantation (autotransplantation) represents a biologically valid alternative to implant therapy, particularly in young patients where implant placement is contraindicated due to ongoing skeletal growth. This approach preserves alveolar bone volume, maintains periodontal proprioception, and allows physiological adaptation over time.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Early loss of permanent teeth due to trauma, extensive caries, or agenesis.

Dental agenesis, particularly involving premolars or incisors, when a suitable donor tooth is available.

Replacement of non-restorable teeth (fractures or destructive caries).

Preservation of alveolar bone in growing patients where implant therapy is contraindicated.

Disqualifiers

Poor patient compliance.

Active infection at the recipient site.

Smoking of more than 15 cigarettes a day

Pregnancy or breastfeeding at date of inclusion

Trial design

Design model

Single group

Treatments tested in this trial

  • Autogenous Tooth Transplantation

    Procedure/Surgery

    After atraumatic extraction of the donor tooth, a simulated apical opening will be created using rotary instruments to induce apical patency and replicate the biological conditions of an open apex, potentially favoring pulpal revascularization.

  • Alveolar Prf graft

    Procedure/Surgery

    To enhance clot formation and promote angiogenesis and tissue regeneration, autologous platelet-rich fibrin (PRF) will be used in the recipient site. PRF Collection and Preparation * Prior to surgery, peripheral venous blood will be collected from the patient using sterile tubes without anticoagulants. * The blood samples will be immediately processed using a standardized centrifugation protocol, allowing the separation of a fibrin matrix enriched with platelets and leukocytes. * After centrifugation, the PRF clot will be gently removed and prepared under sterile conditions for clinical use. PRF Placement * The autologous PRF will be placed directly into the recipient alveolus before positioning the donor tooth. * The PRF matrix will act as a biological scaffold, promoting clot stabilization, neovascularization, and early healing of the periodontal and pulpal tissues.

Treatment groups

5 Participants
are divided into 1 treatment group
Group A: Tooth lossExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Resporption

Rx to evalue internal or external root resorption. Present or Not.

Time frame
1 month, 3 months, 6 months, 1 year, 2 years
2

Vitality

Pulp vitality will be assessed during follow-up using standardized sensibility tests. ( electric test). Vitality : Yes or None

Time frame
1 month, 3 months, 6 months, 1 year, 2 years
3

Mobility

Mobility Test. Grade I, Grade II or Grade III

Time frame
1 month, 3 months, 6 months, 1 year, 2 years
4

Inflammation

signs of inflammation will be monitored. Blood on Probing: Yes or None

Time frame
1 month, 3 months, 6 months, 1 year, 2 years

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Bari Aldo Moro

Lead sponsor

Source ClinicalTrials.gov
Apply now